Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Exploring the Interplay between Complex PTSD and Obsessive-Compulsive Disorder Severity: Implications for Clinical Practice

Martina D'Angelo
,
Marta Valenza
,
Anna Maria Iazzolino
,
Grazia Longobardi
,
Valeria Di Stefano
ORCID logo ,
Elena Lanzara
,
Giulia Visalli
,
Luca Steardo
,
Caterina Scuderi
ORCID logo ,
Luca Steardo jr
*
Version 1 : Received: 13 January 2024 / Approved: 15 January 2024 / Online: 16 January 2024 (10:27:04 CET)

A peer-reviewed article of this Preprint also exists.

D’Angelo, M.; Valenza, M.; Iazzolino, A.M.; Longobardi, G.; Di Stefano, V.; Visalli, G.; Steardo, L.; Scuderi, C.; Manchia, M.; Steardo, L., Jr. Exploring the Interplay between Complex Post-Traumatic Stress Disorder and Obsessive–Compulsive Disorder Severity: Implications for Clinical Practice. Medicina 2024, 60, 408. https://doi.org/10.3390/medicina60030408 D’Angelo, M.; Valenza, M.; Iazzolino, A.M.; Longobardi, G.; Di Stefano, V.; Visalli, G.; Steardo, L.; Scuderi, C.; Manchia, M.; Steardo, L., Jr. Exploring the Interplay between Complex Post-Traumatic Stress Disorder and Obsessive–Compulsive Disorder Severity: Implications for Clinical Practice. Medicina 2024, 60, 408. https://doi.org/10.3390/medicina60030408

Abstract

Background: Traumatic events adversely affect the clinical course of obsessive-compulsive disorder (OCD). Our investigation explores the correlation between prolonged interpersonal trauma and the severity of symptoms related to obsessive-compulsive and anxiety disorders. Methods: The study follows a cross-sectional and observational design, employing the International Trauma Questionnaire (ITQ) to examine areas linked to interpersonal trauma, the Hamilton Anxiety Rating Scale (HAM-A), and the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) to assess anxious and obsessive-compulsive symptoms, respectively. Descriptive analysis, analysis of variance (ANOVA), and logistic regression analyses were conducted. Results: We recruited 107 OCD-diagnosed patients, categorizing them into subgroups based on the presence or absence of complex post-traumatic stress disorder (cPTSD). The ANOVA revealed statistically significant differences between the two groups in the onset age of OCD (p=0.083), psychiatric familial history (p=0.023), HAM-A, and Y-BOCS (p=0.000). Logistic regression indicated a statistically significant association between the presence of cPTSD and Y-BOCS scores (p=0.000). Conclusion: The coexistence of cPTSD in OCD exacerbates obsessive-compulsive symptoms and increases the burden of anxiety. Further advancements in this field are crucial for mitigating the impact of early trauma on the trajectory of OCD and associated anxious symptoms.

Keywords

complex post-traumatic stress disorder; obsessive-compulsive disorder; anxiety

Subject

Medicine and Pharmacology, Psychiatry and Mental Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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