Article
Version 1
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Differential Dysferlin Expression in Rat Muscle
Version 1
: Received: 15 January 2024 / Approved: 16 January 2024 / Online: 16 January 2024 (09:05:12 CET)
How to cite: Meznaric, M.; Angelini, C. Differential Dysferlin Expression in Rat Muscle. Preprints 2024, 2024011216. https://doi.org/10.20944/preprints202401.1216.v1 Meznaric, M.; Angelini, C. Differential Dysferlin Expression in Rat Muscle. Preprints 2024, 2024011216. https://doi.org/10.20944/preprints202401.1216.v1
Abstract
Skeletal muscles are crucial for voluntary movements, and impairments in their function significantly impact our activity. Dysferlin, a protein predominantly present in skeletal muscle, is a focal point of extensive research due to its vital role in muscle repair and maintenance. This study investigates Dysferlin's levels and function in skeletal muscles, emphasizing its significance and the potential effects of its dysregulation on fast and slow muscle fibers. We employed Western blotting on two different rat muscles. The results revealed distinct expressions of Dysferlin in fast and slow fibers, as demonstrated by Western blotting. We propose that Dysferlin may have a metabolic role in addition to its involvement in the repair mechanism.
Keywords
Dysferlin; Western blotting; PAGE; myosin heavy chain isoforms; skeletal muscle; rat; EDL; soleus
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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