Tan, M.; Andersen, L.J.; Bruun, N.E.; Lindholm, M.G.; Tan, Q.; Snoer, M. Transcription Factor Regulation of Gene Expression Network by ZNF385D and HAND2 in Carotid Atherosclerosis. Genes2024, 15, 213.
Tan, M.; Andersen, L.J.; Bruun, N.E.; Lindholm, M.G.; Tan, Q.; Snoer, M. Transcription Factor Regulation of Gene Expression Network by ZNF385D and HAND2 in Carotid Atherosclerosis. Genes 2024, 15, 213.
Tan, M.; Andersen, L.J.; Bruun, N.E.; Lindholm, M.G.; Tan, Q.; Snoer, M. Transcription Factor Regulation of Gene Expression Network by ZNF385D and HAND2 in Carotid Atherosclerosis. Genes2024, 15, 213.
Tan, M.; Andersen, L.J.; Bruun, N.E.; Lindholm, M.G.; Tan, Q.; Snoer, M. Transcription Factor Regulation of Gene Expression Network by ZNF385D and HAND2 in Carotid Atherosclerosis. Genes 2024, 15, 213.
Abstract
Carotid intima-media thickness (CIMT) is a surrogate indicator for atherosclerosis and has been shown to predict cardiovascular risk in multiple large studies. Identifying and characterizing molecular markers for carotid atheroma plaque formation can be critical for early intervention and prevention of atherosclerosis. This study performed transcription factor (TF) network analysis of transcriptomic data focusing on two TF genes, ZNF385D, HAND2, whose polymorphisms reportedly associate with carotid atherosclerosis. Gene expression data were measured from pieces of carotid endarterectomy of hypertensive patients each paired with one sample of distant macroscopically intact tissue. TF networks were reconstructed for ZNF385D and HAND2 and their association with carotid atheroma progression examined using gene-set enrichment analysis with high statistical significance (p<6.95e-7) suggesting involvement of expression quantitative loci (eQTL). Examination of the regulation and correlation patterns suggests high clinical and interventional impacts of the two TF genes on impairing carotid atheroma plaque formation and preventing carotid atherosclerosis.
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