Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Echocardiographic Findings and Subsequent Risk of Native Valve Endocarditis

Juan Andres Quintero-Martinez
* ORCID logo ,
Joya-RIta Hindy
,
Hector R Villarraga
,
Brian D Lahr
,
Mark J Dayer
,
Martin H Thornhill
,
John C O'Horo
,
Hector I Michelena
,
Nandan S Anavekar
,
Parham Sendi
,
Daniel C DeSimone
,
Larry M Baddour
ORCID logo
Version 1 : Received: 11 January 2024 / Approved: 12 January 2024 / Online: 12 January 2024 (07:15:45 CET)

How to cite: Quintero-Martinez, J.A.; Hindy, J.; Villarraga, H.R.; Lahr, B.D.; Dayer, M.J.; Thornhill, M.H.; O'Horo, J.C.; Michelena, H.I.; Anavekar, N.S.; Sendi, P.; DeSimone, D.C.; Baddour, L.M. Echocardiographic Findings and Subsequent Risk of Native Valve Endocarditis. Preprints 2024, 2024010995. https://doi.org/10.20944/preprints202401.0995.v1 Quintero-Martinez, J.A.; Hindy, J.; Villarraga, H.R.; Lahr, B.D.; Dayer, M.J.; Thornhill, M.H.; O'Horo, J.C.; Michelena, H.I.; Anavekar, N.S.; Sendi, P.; DeSimone, D.C.; Baddour, L.M. Echocardiographic Findings and Subsequent Risk of Native Valve Endocarditis. Preprints 2024, 2024010995. https://doi.org/10.20944/preprints202401.0995.v1

Abstract

Background: The association of echocardiographic findings and subsequent risk of left-sided native valve endocarditis (LS-NVE) is undefined. The aim of this study was to determine if transthoracic echocardiographic (TTE) measurements are associated with the subsequent development of LS-NVE in patients without cardiac predisposing conditions. Methods: Institutional databases were evaluated for adults diagnosed with LS-NVE from 2008 to 2020. Patients with prosthetic valves, cardiovascular implantable electronic devices, intracardiac devices, injection drug use, and predisposing cardiac conditions were excluded. Only patients who had a TTE performed 6 months to 3 years before the development of LS-NVE were included as cases. Controls were patients within the same Mayo location with a TTE report and were matched in a 1:3 ratio according to age, gender, Charlson Comorbidity Index, and echocardiography date. Results: There were 148 cases and 431 matched controls. As compared to controls, IE cases had a higher prevalence of diabetes mellitus (46.6% vs. 30.4%) and chronic kidney disease (46.6% vs. 28.1%) (p<0.001). Left ventricular outflow tract velocity (p=0.017), left ventricular ejection fraction (p=0.018), and E: e’ ratio (p=0.050) were associated with LS-NVE. Conclusions: Echocardiographic measurements were associated with subsequent LS-NVE development in this pilot study. A larger cohort of LS-NVE patients, however, is needed to validate these findings.

Keywords

Endocarditis; echocardiography; native valve; left-sided; measurements; risk

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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