Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Beneficial Relationship between Restrictive Diet and Autophagy in Preventing Cancer Cells

Aurelian Udristioiu
ORCID logo ,
Manole Cojocaru
,
Liviu Martin
,
Gabriel Buciu
,
Alexandru Giubelan
,
Marius Marius Stancu
,
Maria Daniela Papurica
,
Ioan-Ovidiu Gheorghe
* ,
Delia Nica-Badea
* ,
Gabriel Petre Gorecki
Version 1 : Received: 25 December 2023 / Approved: 8 January 2024 / Online: 8 January 2024 (14:21:04 CET)

How to cite: Udristioiu, A.; Cojocaru, M.; Martin, L.; Buciu, G.; Giubelan, A.; Marius Stancu, M.; Papurica, M.D.; Gheorghe, I.; Nica-Badea, D.; Gorecki, G.P. The Beneficial Relationship between Restrictive Diet and Autophagy in Preventing Cancer Cells. Preprints 2024, 2024010640. https://doi.org/10.20944/preprints202401.0640.v1 Udristioiu, A.; Cojocaru, M.; Martin, L.; Buciu, G.; Giubelan, A.; Marius Stancu, M.; Papurica, M.D.; Gheorghe, I.; Nica-Badea, D.; Gorecki, G.P. The Beneficial Relationship between Restrictive Diet and Autophagy in Preventing Cancer Cells. Preprints 2024, 2024010640. https://doi.org/10.20944/preprints202401.0640.v1

Abstract

Background A diet rich in red meat, and poor in fruits and vegetables, can hinder the body's ability to detoxify, therefore, an alternative vegetarian diet maintained over a certain period, determines the elimination of excess toxins and accumulated residues, helping the body to regenerate and recharge energy. Following this simple rule, there are a multitude of benefits for our health. Significance of the autophagy process An even better regeneration of the body takes place during the black fast, in which senescent cells, (dead cells that no longer exercise any function, but instead produce inflammation in the body), are eliminated by autophagy, and in their place, the cells are stimulated stem. Aging can be associated with various pathological conditions if autophagy is not promoted by a healthy lifestyle. In elderly people, cells can show DNA mutations and accumulations of protein aggregates that impair the body's physiological processes. Several studies have shown that the activation of autophagy slows down the ageing process. Conclusions Aging, and its associated conditions of illness, are due to genomic instability caused by DNA damage, telomere shortening and epigenome changes that modulate gene expression.

Keywords

autophagy; adenosine triphosphate (ATP); Atg gene; p53 protein

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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