Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

The Clinical Concurrence of Migraine and Transient Global Amnesia: “Migramnesia”?

Version 1 : Received: 4 January 2024 / Approved: 5 January 2024 / Online: 5 January 2024 (11:25:22 CET)

How to cite: Fratalia, L.; Larner, A.J. The Clinical Concurrence of Migraine and Transient Global Amnesia: “Migramnesia”? . Preprints 2024, 2024010486. https://doi.org/10.20944/preprints202401.0486.v1 Fratalia, L.; Larner, A.J. The Clinical Concurrence of Migraine and Transient Global Amnesia: “Migramnesia”? . Preprints 2024, 2024010486. https://doi.org/10.20944/preprints202401.0486.v1

Abstract

Complaint of transient impairment or loss of memory as an attendant feature in some migraine attacks has long been recognised. In some cases, migraine may be a trigger or precipitating factor for the syndrome of transient global amnesia (TGA). However, the exact frequency of this concurrence is unknown, perhaps related to the absence from the International Classification of Headache Disorders (ICHD3) of amnesia or memory loss symptoms in association with migraine, unlike the situation with epileptic seizure (migralepsy) or stroke (migrainous infarction). Similarly, headache has generally been regarded as an incidental feature of TGA, reported in about 10% of cases. We present further examples of TGA in the context of migraine headache; consider possible reasons why this concurrence might be under-recognised, such as the retrograde amnesia characteristic of TGA; review possible shared pathogenetic mechanisms; and suggest a new terminology, “migramnesia”, which may encourage clinicians to address the possible significance of migraine in the context of an episode of TGA.

Keywords

migraine; transient global amnesia

Subject

Medicine and Pharmacology, Neuroscience and Neurology

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