PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Effect of Dolutegravir-Based First-Line Antiretroviral Therapy on Mother-to-Child Transmission of HIV among HIV-Exposed Infants in Southern Ethiopia: A Retrospective Before-After Study
Version 1
: Received: 2 January 2024 / Approved: 3 January 2024 / Online: 3 January 2024 (10:04:30 CET)
How to cite:
Facha, W.; Tadesse, T.; Wolka, E.; Astatkie, A. Effect of Dolutegravir-Based First-Line Antiretroviral Therapy on Mother-to-Child Transmission of HIV among HIV-Exposed Infants in Southern Ethiopia: A Retrospective Before-After Study. Preprints2024, 2024010131. https://doi.org/10.20944/preprints202401.0131.v1
Facha, W.; Tadesse, T.; Wolka, E.; Astatkie, A. Effect of Dolutegravir-Based First-Line Antiretroviral Therapy on Mother-to-Child Transmission of HIV among HIV-Exposed Infants in Southern Ethiopia: A Retrospective Before-After Study. Preprints 2024, 2024010131. https://doi.org/10.20944/preprints202401.0131.v1
Facha, W.; Tadesse, T.; Wolka, E.; Astatkie, A. Effect of Dolutegravir-Based First-Line Antiretroviral Therapy on Mother-to-Child Transmission of HIV among HIV-Exposed Infants in Southern Ethiopia: A Retrospective Before-After Study. Preprints2024, 2024010131. https://doi.org/10.20944/preprints202401.0131.v1
APA Style
Facha, W., Tadesse, T., Wolka, E., & Astatkie, A. (2024). Effect of Dolutegravir-Based First-Line Antiretroviral Therapy on Mother-to-Child Transmission of HIV among HIV-Exposed Infants in Southern Ethiopia: A Retrospective Before-After Study. Preprints. https://doi.org/10.20944/preprints202401.0131.v1
Chicago/Turabian Style
Facha, W., Eskinder Wolka and Ayalew Astatkie. 2024 "Effect of Dolutegravir-Based First-Line Antiretroviral Therapy on Mother-to-Child Transmission of HIV among HIV-Exposed Infants in Southern Ethiopia: A Retrospective Before-After Study" Preprints. https://doi.org/10.20944/preprints202401.0131.v1
Abstract
Background: Currently, a Dolutegravir (DTG)-based regimen is administered to women on option B plus to prevent mother-to-child transmission (MTCT) of the virus. However, its effect on reducing MTCT of human immunodeficiency virus (HIV) among exposed infants over the previously used Efavirenz (EFV)-based regimen is unknown. Objective: This study aimed to compare the effects of DTG-based and EFV-based regimens on the MTCT of HIV among exposed infants in southern Ethiopia. Methods:A retrospective before-after study design was employed from March to May 2023 among 958 mother-infant pairs (479 on EFV-based and 479 on DTG-based regimens) enrolled in the prevent mother-to-child transmission (PMTCT) care from September 2015 to February 2023. The outcome variable was the HIV infection status among the exposed infants. A log-binomial model was employed and the proportion was computed to compare the incidence of MTCT of HIV in both groups. The risk ratio (RR) with 95% confidence interval (CI) was calculated to assess the predictor variables. Results:Mothers on a DTG-based regimen were approximately 44% (adjusted risk ratio (aRR): 0.56; 95% CI: 0.44, 0.70) less likely to transmit HIV to their infants than those on an EFV-based regimen. In addition, poor/fair adherence to antiretroviral therapy (ART) (aRR: 5.82; 95% CI: 3.41, 9.93), home delivery (aRR: 3.61; 95% CI: 2.32, 5.62), mixed feeding practice (aRR: 1.83; 95% CI: 1.45, 2.3), and not receiving antiretroviral prophylaxis (aRR: 3.26; 95% CI: 1.6, 6.64) were found to increase the risk of MTCT of HIV infection, whereas older maternal age (aRR: 0.93; 95% CI: 0.9, 0.96) was a protective factor.Conclusion:TheDolutegravir-based regimen significantly reduced MTCT of HIV among exposed infants compared to the EFV-based regimen. Thus, DTG-based first-line ART regimen supplementation should be sustained to achieve global and national targets for zero new infections in HIV-exposed infants.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
