Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Association of Alkaline Phosphatase with Cardiovascular Disease in Patients with Dyslipidemia: A 6-Year Retrospective Study

Petros-Spyridonas Adamidis
,
Matilda Florentin
ORCID logo ,
Evangelos Liberopoulos
,
Amalia Despoina Koutsogianni
,
Georgia Anastasiou
,
George Liamis
,
Haralampos Milionis
,
Fotios Barkas
* ORCID logo
Version 1 : Received: 1 January 2024 / Approved: 2 January 2024 / Online: 3 January 2024 (07:37:59 CET)

A peer-reviewed article of this Preprint also exists.

Adamidis, P.S.; Florentin, M.; Liberopoulos, E.; Koutsogianni, A.D.; Anastasiou, G.; Liamis, G.; Milionis, H.; Barkas, F. Association of Alkaline Phosphatase with Cardiovascular Disease in Patients with Dyslipidemia: A 6-Year Retrospective Study. J. Cardiovasc. Dev. Dis. 2024, 11, 60. Adamidis, P.S.; Florentin, M.; Liberopoulos, E.; Koutsogianni, A.D.; Anastasiou, G.; Liamis, G.; Milionis, H.; Barkas, F. Association of Alkaline Phosphatase with Cardiovascular Disease in Patients with Dyslipidemia: A 6-Year Retrospective Study. J. Cardiovasc. Dev. Dis. 2024, 11, 60.

Abstract

Background and Aim: Serum alkaline phosphatase (ALP) activity has been associated with ath-erosclerotic cardiovascular disease (ASCVD). We aimed to investigate the association of ALP with ASCVD in patients with dyslipidemia. Methods: Retrospective cohort study including consecutive adults with dyslipidemia followed-up for ≥3 years (from 1999 to 2022) in the outpatient Lipid Clinic of Ioannina University General Hospital, Greece. The primary endpoint was the association between baseline ALP and incident ASCVD after adjusting for traditional risk factors (i.e. sex, age, hypertension, diabetes, smoking, dyslipidemia), baseline ASCVD and lipid-lowering treatment. ALP levels were stratified by ter-tiles as follows: low:<67 U/L, middle: 67-79 U/L, high: ≥79 U/L. Results: Overall, 1178 subjects were included; 44% were males and their median age was 57 years (range 49-65). During a 6-year median follow-up (interquartile range IQR: 4-9), 78 new ASCVD events (6.6%) occurred. A statistically significant association between baseline ALP levels and incident ASCVD was demonstrated (Odds Ratio, OR: 6.99, 95% Confidence Interval, CI: 2.29-21.03, p=0.001). Subjects in the highest ALP tertile had the highest odds for ASCVD when compared with those in the lowest tertile (OR: 2.35; 95% CI: 1.24-4.41, p=0.008). Conclusions: The present study demonstrated that ALP is associated with ASCVD development in patients with dyslipidemia.

Keywords

alkaline phosphatase; cardiovascular disease; cholesterol; statins

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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