Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Calorie Restriction and Time-Restricted Feeding: Effective Interventions in Overweight or Obese Patients Undergoing Radiotherapy Treatment with Curative Intent for Cancer

Carmen Vega
ORCID logo ,
Esteban Barnafi
ORCID logo ,
César Sánchez
,
Francisco Acevedo
,
Benjamin Walbaum
,
Alejandra Parada
,
Nicolás Rivas
,
Tomás Merino
*
Version 1 : Received: 27 December 2023 / Approved: 28 December 2023 / Online: 28 December 2023 (15:18:07 CET)

A peer-reviewed article of this Preprint also exists.

Vega, C.; Barnafi, E.; Sánchez, C.; Acevedo, F.; Walbaum, B.; Parada, A.; Rivas, N.; Merino, T. Calorie Restriction and Time-Restricted Feeding: Effective Interventions in Overweight or Obese Patients Undergoing Radiotherapy Treatment with Curative Intent for Cancer. Nutrients 2024, 16, 477. Vega, C.; Barnafi, E.; Sánchez, C.; Acevedo, F.; Walbaum, B.; Parada, A.; Rivas, N.; Merino, T. Calorie Restriction and Time-Restricted Feeding: Effective Interventions in Overweight or Obese Patients Undergoing Radiotherapy Treatment with Curative Intent for Cancer. Nutrients 2024, 16, 477.

Abstract

Breast and prostate cancer lead incidence rankings in Chile, with obesity and overweight as important risk factors involved in prognosis. Nutritional interventions have shown to be beneficial therapies in patients with cancer, improving anthropometric and biochemical measurements. This study investigates the feasibility and effectiveness of Calorie Restriction and Time-Restricted Feeding in overweight or obese patients undergoing curative radiotherapy for breast and prostate cancer. The research was conducted as a prospective, interventional, non-randomized clinical trial, involving 27 participants, of whom 23 completed the study. Findings indicate that both interventions are feasible and effective. Notably, Time-Restricted Feeding demonstrated superior adherence and more significant improvements in weight loss and metabolic parameters. A mean weight reduction of 3.6 kg and waist circumference decrease of 4.9 cm was observed across participants. Serum levels of glucose, insulin, LDL, HDL and TG showed an average reduction, indicating positive metabolic changes. Results suggest that Time-Restricted Feeding could be a superior beneficial dietary intervention for cancer patients undergoing radiotherapy, due to its ease of adherence and positive impact on metabolic health. This research contributes to the growing evidence on the role of nutritional interventions in cancer treatment and underscores the need for more extensive studies to validate these findings.

Keywords

Intermittent Fasting; Cancer; Curative; Radiotherapy; Calorie Restriction; Time-Restricted Feeding; Diet; Nutrition; Overweight; Obese

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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