Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Synthesis of Substituted Pyrrole Derivatives Based on 8-azaspiro[5.6]dodec-10-ene Scaffold

Version 1 : Received: 26 December 2023 / Approved: 26 December 2023 / Online: 27 December 2023 (04:20:47 CET)

A peer-reviewed article of this Preprint also exists.

Iusupov, I.R.; Tafeenko, V.A.; Altieri, A.; Kurkin, A.V. Synthesis of Substituted Pyrrole Derivatives Based on 8-Azaspiro[5.6]dodec-10-ene Scaffold. Molbank 2024, 2024, M1765. Iusupov, I.R.; Tafeenko, V.A.; Altieri, A.; Kurkin, A.V. Synthesis of Substituted Pyrrole Derivatives Based on 8-Azaspiro[5.6]dodec-10-ene Scaffold. Molbank 2024, 2024, M1765.

Abstract

This work describes the synthesis and X-ray diffraction properties of spirocyclic compounds based on 8-azaspiro[5.6]dodec-10-ene. Diasteriomerically pure pyrrole derivatives were prepared from the spirocyclic 1,2,3-triazole using a coupling reaction. The resulting compounds were characterized via 1H and 13C NMR spectroscopy and HRMS, and the crystallographic characteristics of one of them were studied by X-ray diffraction.

Keywords

spirocycle; pyrrole; 1,2,3-triazole, azaspiro

Subject

Chemistry and Materials Science, Organic Chemistry

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