Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Enhanced Hemostatic and Procoagulant Efficacy of PEG/ZnO Hydrogels: A Novel Approach in Traumatic Hemorrhage Management

Chuyue Zhang
ORCID logo ,
Yifan Wang
,
Yuan Xue
,
Pengfei Chi
,
Zhaohan Wang
,
Bo Li
,
Taoxu Yan
,
Junyao Cheng
,
Bing Wu
,
Zheng Wang
*
Version 1 : Received: 20 December 2023 / Approved: 21 December 2023 / Online: 22 December 2023 (09:42:47 CET)

A peer-reviewed article of this Preprint also exists.

Zhang, C.; Wang, Y.; Xue, Y.; Cheng, J.; Chi, P.; Wang, Z.; Li, B.; Yan, T.; Wu, B.; Wang, Z. Enhanced Hemostatic and Procoagulant Efficacy of PEG/ZnO Hydrogels: A Novel Approach in Traumatic Hemorrhage Management. Gels 2024, 10, 88. Zhang, C.; Wang, Y.; Xue, Y.; Cheng, J.; Chi, P.; Wang, Z.; Li, B.; Yan, T.; Wu, B.; Wang, Z. Enhanced Hemostatic and Procoagulant Efficacy of PEG/ZnO Hydrogels: A Novel Approach in Traumatic Hemorrhage Management. Gels 2024, 10, 88.

Abstract

Managing severe bleeding, particularly in soft tissues and visceral injuries, remains a significant challenge in trauma and surgical care. Traditional hemostatic methods often fall short in wet and dynamic environments. This study addresses the critical issue of severe bleeding in soft tissues, proposing an innovative solution using a Polyethylene Glycol (PEG)-based hydrogel combined with zinc oxide (ZnO). The developed hydrogel forms a dual-network structure through amide bonds and metal ion chelation, resulting in enhanced mechanical properties and adhesion strength. The hydrogel, exhibiting excellent biocompatibility, is designed to release zinc ions, promoting coagulation and accelerating hemostasis. Comprehensive characterization, including gelation time, rheological properties, microstructure analysis, and swelling behavior, demon-strates the superior performance of the PEG/ZnO hydrogel compared to traditional PEG hydro-gels. Mechanical tests confirm increased compression strength and adhesive properties, crucial for withstanding tissue dynamics. In vitro assessments reveal excellent biocompatibility and en-hanced procoagulant ability attributed to ZnO. Moreover, in vivo experiments using rat liver and tail bleeding models demonstrate the remarkable hemostatic performance of the PEG/ZnO hy-drogel, showcasing its potential for acute bleeding treatment in both visceral and peripheral sce-narios.

Keywords

Hemostasis; Polyethylene Glycol; Zinc Oxide; Trauma Care; Visceral Injuries

Subject

Medicine and Pharmacology, Emergency Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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