Liu, Z.; Sun, W.; Hu, Z.; Wang, W.; Zhang, H. Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade. Mar. Drugs2024, 22, 51.
Liu, Z.; Sun, W.; Hu, Z.; Wang, W.; Zhang, H. Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade. Mar. Drugs 2024, 22, 51.
Liu, Z.; Sun, W.; Hu, Z.; Wang, W.; Zhang, H. Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade. Mar. Drugs2024, 22, 51.
Liu, Z.; Sun, W.; Hu, Z.; Wang, W.; Zhang, H. Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade. Mar. Drugs 2024, 22, 51.
Abstract
Natural alkaloids of actinomycetes origin and synthetic derivatives have always been among the important suppliers of small-molecule drugs. Among their biological sources, Streptomyces is the highest and most extensively researched genus. Marine-derived Streptomyces strains harbor unconventional metabolic pathways and have been demonstrated to be efficient producers of biologically active alkaloids since more than 60% of these compounds exhibit valuable activity such as antibacterial, antitumor, anti-inflammatory activity, etc. This review comprehensively summarizes novel alkaloids produced by marine Streptomyces discovered in the past decade, focusing on their structural features, biological activity and pharmacological mechanisms. Future perspectives on the discovery and development of novel alkaloids from marine Streptomyces are also provided.
Keywords
marine Streptomyces; alkaloid; secondary metabolite; discovery; development
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
