Version 1
: Received: 17 December 2023 / Approved: 17 December 2023 / Online: 28 December 2023 (09:07:01 CET)
How to cite:
Abdelkhalik, M.M.; Alnajjar, A.; Ibrahim, S.M.; Raslan, M.A.; Sadek, K.U. A Simple and Efficient Multicomponent Synthesis of Novel Pyrazole, N-aminopyridine and Pyrazolo[3,4-b]Pyridine Derivatives in Water. Preprints2023, 2023121232. https://doi.org/10.20944/preprints202312.1232.v1
Abdelkhalik, M.M.; Alnajjar, A.; Ibrahim, S.M.; Raslan, M.A.; Sadek, K.U. A Simple and Efficient Multicomponent Synthesis of Novel Pyrazole, N-aminopyridine and Pyrazolo[3,4-b]Pyridine Derivatives in Water. Preprints 2023, 2023121232. https://doi.org/10.20944/preprints202312.1232.v1
Abdelkhalik, M.M.; Alnajjar, A.; Ibrahim, S.M.; Raslan, M.A.; Sadek, K.U. A Simple and Efficient Multicomponent Synthesis of Novel Pyrazole, N-aminopyridine and Pyrazolo[3,4-b]Pyridine Derivatives in Water. Preprints2023, 2023121232. https://doi.org/10.20944/preprints202312.1232.v1
APA Style
Abdelkhalik, M.M., Alnajjar, A., Ibrahim, S.M., Raslan, M.A., & Sadek, K.U. (2023). A Simple and Efficient Multicomponent Synthesis of Novel Pyrazole, N-aminopyridine and Pyrazolo[3,4-b]Pyridine Derivatives in Water. Preprints. https://doi.org/10.20944/preprints202312.1232.v1
Chicago/Turabian Style
Abdelkhalik, M.M., Mohammed Abdelmonem Raslan and Kamal Usef Sadek. 2023 "A Simple and Efficient Multicomponent Synthesis of Novel Pyrazole, N-aminopyridine and Pyrazolo[3,4-b]Pyridine Derivatives in Water" Preprints. https://doi.org/10.20944/preprints202312.1232.v1
Abstract
The three-component reaction of enaminones, benzaldehyde and hydrazine-HCl or four-component reaction of enaminones, benzaldehyde, hydrazine–HCl and ethyl cyanoacetate in water in the presence of catalytic amount of ammonium acetate has been devised as a straightforward , sustainable approach for the synthesis of 1-H-pyrazole, N-aminopyridine and pyrazol[3,4-b]pyridine derivatives . The key benefits of this approach is simple experimental procedure associated with cost effective and environmentally friendly techniques.
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
