Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Evaluation of the Immunosafety of Cucurbit[n]uril In Vivo

Ekaterina Pashkina
* ORCID logo ,
Alina Aktanova
,
Olga Boeva
ORCID logo ,
Maria Bykova
,
Elena Gavrilova
,
Elena Goiman
,
Ekaterina Kovalenko
,
Na'il Saleh
ORCID logo ,
Lyubov Grishina
,
Vladimir Aleksandrovich Kozlov
Version 1 : Received: 11 December 2023 / Approved: 11 December 2023 / Online: 11 December 2023 (15:17:52 CET)

A peer-reviewed article of this Preprint also exists.

Pashkina, E.; Aktanova, A.; Boeva, O.; Bykova, M.; Gavrilova, E.; Goiman, E.; Kovalenko, E.; Saleh, N.; Grishina, L.; Kozlov, V. Evaluation of the Immunosafety of Cucurbit[n]uril In Vivo. Pharmaceutics 2024, 16, 127. Pashkina, E.; Aktanova, A.; Boeva, O.; Bykova, M.; Gavrilova, E.; Goiman, E.; Kovalenko, E.; Saleh, N.; Grishina, L.; Kozlov, V. Evaluation of the Immunosafety of Cucurbit[n]uril In Vivo. Pharmaceutics 2024, 16, 127.

Abstract

. Cucurbiturils are a family of macrocyclic oligomers capable of forming host-guest complexes with various molecules. Due to noncovalent binding to drug molecules and low toxicity, cucurbiturils has been extensively investigated as a potential carrier for drug delivery. However, the immune system interactions with different drug carriers, including cucurbiturils, are still under investigation. In this study, we focused on cucurbiturils immunosafety and immunomodulation properties in vivo. We measured blood counts, lymphocyte subpopulations in blood, spleen, and bone marrow, and assessed in vivo toxicity to spleen and bone marrow cells after intraperitoneal administration to mice. We also evaluated the effect of cucurbiturils on cellular and humoral immune responses. Cucurbiturils in high concentrations effect on the immune system in vivo. The action of various cucurbiturils differs in different homologues, which, apparently, is associated with different interactions in the internal environment of the body.

Keywords

nanoparticles; cucurbiturils; blood cells; immune system.

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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