Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Unveiling the Armory: A Comprehensive Review on Antimicrobial Peptides - Classification and Diverse Applications across Disease Landscapes

Version 1 : Received: 4 December 2023 / Approved: 6 December 2023 / Online: 7 December 2023 (07:25:37 CET)

How to cite: K., A.R.; Sahoo, S.S.; Agarkar, B.S. Unveiling the Armory: A Comprehensive Review on Antimicrobial Peptides - Classification and Diverse Applications across Disease Landscapes. Preprints 2023, 2023120434. https://doi.org/10.20944/preprints202312.0434.v1 K., A.R.; Sahoo, S.S.; Agarkar, B.S. Unveiling the Armory: A Comprehensive Review on Antimicrobial Peptides - Classification and Diverse Applications across Disease Landscapes. Preprints 2023, 2023120434. https://doi.org/10.20944/preprints202312.0434.v1

Abstract

Antimicrobial peptides (AMPs) are essential components of the innate immune system, present across a spectrum of organisms. Their versatility lies in their ability to effectively inhibit a wide range of pathogens including bacteria, fungi, parasites, and viruses. As the challenge of antibiotic resistance escalates and concerns surrounding antibiotic use grow, AMPs have emerged as promising alternatives. Their applications span diverse domains such as medicine, agriculture, food production, animal husbandry, and aquaculture, primarily due to their efficacy against resistant pathogens, signifying their crucial role in combating infections. Beyond their antimicrobial properties, research illuminates their intricate involvement in the immune response network. These peptides impact crucial processes including cytokine release, chemotaxis, wound healing, angiogenesis and the activation of the adaptive immune system. This comprehensive review delves into the multifaceted realm of AMPs, encompassing their classification, varied applications across industries and notably, their significance in diverse disease conditions like infections, skin diseases, cancer, oral diseases, lung diseases and cardiovascular ailments. Special attention is directed towards current advancements in clinical applications of peptide-based therapeutics, offering invaluable insights into their potential future integration within clinical settings.

Keywords

Antimicrobial peptides; Classification; Disease conditions; Therapeutic action and Clinical advancements

Subject

Public Health and Healthcare, Public Health and Health Services

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