Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Gas Phase Transformations in Carbon-11 Chemistry

Version 1 : Received: 4 December 2023 / Approved: 6 December 2023 / Online: 6 December 2023 (10:11:46 CET)

A peer-reviewed article of this Preprint also exists.

Lu, S.; Telu, S.; Siméon, F.G.; Cai, L.; Pike, V.W. Gas Phase Transformations in Carbon-11 Chemistry. Int. J. Mol. Sci. 2024, 25, 1167. Lu, S.; Telu, S.; Siméon, F.G.; Cai, L.; Pike, V.W. Gas Phase Transformations in Carbon-11 Chemistry. Int. J. Mol. Sci. 2024, 25, 1167.

Abstract

The short-lived positron-emitter carbon-11 (t1/2 = 20.4 min; b+, 99.8%) is prominent for labeling tracers for use in biomedical research with positron emission tomography (PET). Carbon-11 is produced for this purpose with a cyclotron, nowadays almost exclusively by the 14N(p,a)11C nuclear reaction, either on nitrogen containing a low concentration of oxygen (0.1–0.5%) or hydrogen (~ 5%) to produce [11C]carbon dioxide or [11C]methane, respectively. These primary radioactive products can be produced in high yields and with high molar activities. However, only [11C]carbon dioxide has some utility for directly labeling PET tracers. Primary products are required to be converted rapidly and efficiently into secondary labeling synthons to provide versatile radiochemistry for labeling diverse tracer chemotypes at molecular positions of choice. This review surveys known gas phase transformations of carbon-11 and summarizes the important roles that many of these transformations now play for producing a broad range of labeling synthons in carbon-11 chemistry.

Keywords

Carbon-11; Gas phase; Catalysts; On-line; Radiotracer; Radiochemistry; PET

Subject

Chemistry and Materials Science, Organic Chemistry

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.