Boira, C.; Meunier, M.; Bracq, M.; Scandolera, A.; Reynaud, R. The Natural Centella asiatica Extract Acts as a Stretch Mark Eraser: A Biological Evaluation. Cosmetics2024, 11, 15.
Boira, C.; Meunier, M.; Bracq, M.; Scandolera, A.; Reynaud, R. The Natural Centella asiatica Extract Acts as a Stretch Mark Eraser: A Biological Evaluation. Cosmetics 2024, 11, 15.
Boira, C.; Meunier, M.; Bracq, M.; Scandolera, A.; Reynaud, R. The Natural Centella asiatica Extract Acts as a Stretch Mark Eraser: A Biological Evaluation. Cosmetics2024, 11, 15.
Boira, C.; Meunier, M.; Bracq, M.; Scandolera, A.; Reynaud, R. The Natural Centella asiatica Extract Acts as a Stretch Mark Eraser: A Biological Evaluation. Cosmetics 2024, 11, 15.
Abstract
Stretch marks are far from being exclusively appearing on pregnant women and appear whenever the body experience a rapid growth. Into the dermis, collagen fibres are altered associated with a loss of orientation and the elastic network is disrupted leading to a fibrotic organisation. This results to epidermal tearing which produce skin lesions. Centella asiatica is a well-known medicinal plants rich in triterpenic actives molecules and traditionally used to treat wounds and help skin repair. The aim of this study was to evaluate Centella asiatica extract as a natural way to solve stretch marks concern and understand its mechanism of action. We have first evaluated the fibroblast’s proliferation based on scratch assay model and their genes expression by RT-qPCR. At the ex vivo level, elastin fibres were quantified by immunofluorescence. Collagen fibre’s orientation and their occupation of the dermis were analysed after Sirius red staining and specific software analysis. We have proven that Centella asiatica has stimulated fibroblasts proliferation, reduced extracellular matrix degradation and fibrosis. On stretch marked skin explant, Centella asiatica increased the occupation of collagen fibres and elastin production. Based on the mechanisms behind the formation of stretch marks, Centella asiatica restores dermis network by optimising fibres organisation for a visible skin remodelling effect.
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