Makena, P.; Baxter-Write, S.; Jones, B.; Chen, P.; Prasad, G.L. Clinical Evaluation of Alveolar Permeability as a Biomarker of Potential Harm. Preprints2023, 2023120349. https://doi.org/10.20944/preprints202312.0349.v1
APA Style
Makena, P., Baxter-Write, S., Jones, B., Chen, P., & Prasad, G.L. (2023). Clinical Evaluation of Alveolar Permeability as a Biomarker of Potential Harm. Preprints. https://doi.org/10.20944/preprints202312.0349.v1
Chicago/Turabian Style
Makena, P., Peter Chen and Gaddamanugu L Prasad. 2023 "Clinical Evaluation of Alveolar Permeability as a Biomarker of Potential Harm" Preprints. https://doi.org/10.20944/preprints202312.0349.v1
Abstract
The lung epithelium regulates gas exchange and is the first line of defense against airborne toxicants and microbial infections. Disruption of the integrity of lung epithelium results in altered permeability and severely impacts normal lung functions. To develop biomarkers of potential harm (BoPH) for assessing adverse health effects of cigarette smoking, we have evaluated lung barrier function. In a single-center, ambulatory, clinical study we measured lung permeability, as the half-life (T1/2) of inhaled 99mTC-DTPA, in 17 subjects consisting of 6 Smokers (SMK), 5 Moist Snuff Consumers (MSC), and 6 Non-Tobacco Consumers (NTC) at three weekly test visits. Smokers, relative to MSC and NTC, exhibited significantly faster clearance of the inhaled probe (shorter T1/2), indicating increased lung permeability. NTC and MSC had comparable clearance times of the inhaled probe (longer T1/2). Least squares regression modeling showed that the variability of the test was minimal and was not significant. Prediction profiling showed that the repeatability of the lung permeability test was robust and was able to differentiate the tobacco product use groups in this study. Thus, altered lung barrier function may serve as a BoPH for assessing the effects of tobacco use.
Keywords
inhaled 99mTC-DTPA; lung permeability; smoking
Subject
Biology and Life Sciences, Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
