Neymash, A.O.; Ulomsky, E.N.; Fedotov, V.V.; Aminov, S.V.; Lyapustin, D.V.; Gorbunov, E.B.; Ishimnikov, V.A.; Slepukhin, P.A.; Rusinov, V.L. Reconstructive Methodology in the Synthesis of 2-Aminopurine. Molecules2024, 29, 134.
Neymash, A.O.; Ulomsky, E.N.; Fedotov, V.V.; Aminov, S.V.; Lyapustin, D.V.; Gorbunov, E.B.; Ishimnikov, V.A.; Slepukhin, P.A.; Rusinov, V.L. Reconstructive Methodology in the Synthesis of 2-Aminopurine. Molecules 2024, 29, 134.
Neymash, A.O.; Ulomsky, E.N.; Fedotov, V.V.; Aminov, S.V.; Lyapustin, D.V.; Gorbunov, E.B.; Ishimnikov, V.A.; Slepukhin, P.A.; Rusinov, V.L. Reconstructive Methodology in the Synthesis of 2-Aminopurine. Molecules2024, 29, 134.
Neymash, A.O.; Ulomsky, E.N.; Fedotov, V.V.; Aminov, S.V.; Lyapustin, D.V.; Gorbunov, E.B.; Ishimnikov, V.A.; Slepukhin, P.A.; Rusinov, V.L. Reconstructive Methodology in the Synthesis of 2-Aminopurine. Molecules 2024, 29, 134.
Abstract
A fundamentally new synthetic approach to the synthesis of 2-aminopurine has been developed. It consists in the combination of creation of condensed polyazotic heterocyclic tetrazolopyrimidine structure, it’s transformation into triaminopyrimidine and subsequent cyclization into 2-aminopurine. The structure of the obtained compounds was established based on spectral characteristics and intermediate 5 directly by X-ray diffraction analysis.
Keywords
tetrazololopyrimidines; purines; reduction; nitro group transformations; condensation; reconstructive methodology
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
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