Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Reconstructive Methodology in the Synthesis of 2-Aminopurine

Version 1 : Received: 5 December 2023 / Approved: 6 December 2023 / Online: 6 December 2023 (10:40:30 CET)

A peer-reviewed article of this Preprint also exists.

Neymash, A.O.; Ulomsky, E.N.; Fedotov, V.V.; Aminov, S.V.; Lyapustin, D.V.; Gorbunov, E.B.; Ishimnikov, V.A.; Slepukhin, P.A.; Rusinov, V.L. Reconstructive Methodology in the Synthesis of 2-Aminopurine. Molecules 2024, 29, 134. Neymash, A.O.; Ulomsky, E.N.; Fedotov, V.V.; Aminov, S.V.; Lyapustin, D.V.; Gorbunov, E.B.; Ishimnikov, V.A.; Slepukhin, P.A.; Rusinov, V.L. Reconstructive Methodology in the Synthesis of 2-Aminopurine. Molecules 2024, 29, 134.

Abstract

A fundamentally new synthetic approach to the synthesis of 2-aminopurine has been developed. It consists in the combination of creation of condensed polyazotic heterocyclic tetrazolopyrimidine structure, it’s transformation into triaminopyrimidine and subsequent cyclization into 2-aminopurine. The structure of the obtained compounds was established based on spectral characteristics and intermediate 5 directly by X-ray diffraction analysis.

Keywords

tetrazololopyrimidines; purines; reduction; nitro group transformations; condensation; reconstructive methodology

Subject

Chemistry and Materials Science, Organic Chemistry

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