NMR-Based Metabolomics of Non-Human Primate Ocular Tissues: A Dataset

Vadim V. Yanshole; Maxim V. Fomenko; Lyudmila V. Yanshole; Nataliya A. Osik; Elena Y. Radomskaya; Dmitry V. Bulgin; Yuri P. Tsentalovich

doi:10.20944/preprints202312.0072.v1

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202312.0072.v1

Preprint Data Descriptor Version 1 Preserved in Portico This version is not peer-reviewed

NMR-Based Metabolomics of Non-Human Primate Ocular Tissues: A Dataset

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Version 1 : Received: 21 November 2023 / Approved: 1 December 2023 / Online: 4 December 2023 (02:13:54 CET)

How to cite: Yanshole, V.V.; Fomenko, M.V.; Yanshole, L.V.; Osik, N.A.; Radomskaya, E.Y.; Bulgin, D.V.; Tsentalovich, Y.P. NMR-Based Metabolomics of Non-Human Primate Ocular Tissues: A Dataset. Preprints 2023, 2023120072. https://doi.org/10.20944/preprints202312.0072.v1 Yanshole, V.V.; Fomenko, M.V.; Yanshole, L.V.; Osik, N.A.; Radomskaya, E.Y.; Bulgin, D.V.; Tsentalovich, Y.P. NMR-Based Metabolomics of Non-Human Primate Ocular Tissues: A Dataset. Preprints 2023, 2023120072. https://doi.org/10.20944/preprints202312.0072.v1

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MDPI and ACS Style

Yanshole, V.V.; Fomenko, M.V.; Yanshole, L.V.; Osik, N.A.; Radomskaya, E.Y.; Bulgin, D.V.; Tsentalovich, Y.P. NMR-Based Metabolomics of Non-Human Primate Ocular Tissues: A Dataset. Preprints 2023, 2023120072. https://doi.org/10.20944/preprints202312.0072.v1

APA Style

Yanshole, V.V., Fomenko, M.V., Yanshole, L.V., Osik, N.A., Radomskaya, E.Y., Bulgin, D.V., & Tsentalovich, Y.P. (2023). NMR-Based Metabolomics of Non-Human Primate Ocular Tissues: A Dataset. Preprints. https://doi.org/10.20944/preprints202312.0072.v1

Chicago/Turabian Style

Yanshole, V.V., Dmitry V. Bulgin and Yuri P. Tsentalovich. 2023 "NMR-Based Metabolomics of Non-Human Primate Ocular Tissues: A Dataset" Preprints. https://doi.org/10.20944/preprints202312.0072.v1

Abstract

Model animals are employed in experiments as substitutes for human tissues and fluids, particularly when accessing particular human samples (such as cerebrospinal fluid, brain, ocular tissues, etc.) poses significant challenges or is ethically constrained. Nonhuman primates are frequently regarded as superior animal models for investigating human ophthalmological diseases. However, despite this recognition, the metabolomic composition of ocular tissues in non-human primates remains predominantly unexplored. In this work, we present a dataset on metabolite concentrations in serum and ocular tissues, including aqueous humor (AH), vitreous humor (VH), and lens, in two Macaque species: crab-eating macaque (Macaca fascicularis) and rhesus macaque (Macaca mulatta). A total of 99 compounds were quantified in 45 samples, shedding light on the previously unknown metabolomic profiles of primate eye tissues.

Keywords

quantitative metabolomics; NMR spectroscopy; eye tissues; serum; animal models; monkeys

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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