Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Palladium-Catalyzed β-C(sp3)–H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands

Version 1 : Received: 30 November 2023 / Approved: 30 November 2023 / Online: 30 November 2023 (05:45:42 CET)

A peer-reviewed article of this Preprint also exists.

Xu, Z.; Li, Z.; Liu, C.; Yang, K.; Ge, H. Palladium-Catalyzed β-C(sp3)–H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands. Molecules 2024, 29, 259. Xu, Z.; Li, Z.; Liu, C.; Yang, K.; Ge, H. Palladium-Catalyzed β-C(sp3)–H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands. Molecules 2024, 29, 259.

Abstract

2-Pyridone ligand-facilitated palladium-catalyzed direct C–H bond functionalization via the transient directing group strategy has become an attractive topic. Here we report a Pd-catalyzed direct β-C(sp3) –H arylation reaction of tertiary aliphatic aldehydes by using an α-amino acid as a transient directing group in combination with a 2-pyridone ligand.

Keywords

palladium-catalyzed; 2-pyridone ligand; tertiary aldehydes

Subject

Chemistry and Materials Science, Organic Chemistry

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