Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Impact of COVID-19 Vaccination on Autoimmune Disorders: A Descriptive Analysis

Version 1 : Received: 27 November 2023 / Approved: 28 November 2023 / Online: 29 November 2023 (15:25:59 CET)

How to cite: Ghosh, A.; Larrondo-Petrie, M.M.; Pavlovic, M. The Impact of COVID-19 Vaccination on Autoimmune Disorders: A Descriptive Analysis. Preprints 2023, 2023111901. https://doi.org/10.20944/preprints202311.1901.v1 Ghosh, A.; Larrondo-Petrie, M.M.; Pavlovic, M. The Impact of COVID-19 Vaccination on Autoimmune Disorders: A Descriptive Analysis. Preprints 2023, 2023111901. https://doi.org/10.20944/preprints202311.1901.v1

Abstract

The COVID-19 pandemic has had a substantial impact on global health, notably the virus's association with autoimmune illnesses. Autoimmune illnesses occur when the immune system of the body targets healthy cells, causing damage and inflammation. The potential impact of COVID-19 on autoimmune disorders, the hazards of COVID-19 vaccinations for persons with autoimmune diseases, and the potential risks of COVID-19 vaccines are all discussed in this essay. COVID-19 can cause autoimmune illnesses by causing inflammation, organ and tissue damage, and molecular mimicry, in which the immune system mistakenly assaults healthy cells for the virus. However, not everyone infected with COVID-19 develops autoimmune disorders. While some research has found a link between COVID-19 and autoimmune illnesses, this does not always suggest causation. Other factors, such as genetics and environment, may also play a role in the emergence of autoimmune illnesses. COVID-19 can aggravate existing autoimmune disorders by causing the immune system to attack healthy cells, making management more difficult and increasing the risk of consequences. People with autoimmune disorders, on the other hand, may not be at a higher risk of severe COVID-19 than the general population. Some research has found that persons with autoimmune disorders are more likely to have severe COVID-19, whereas others have found no difference. COVID-19 vaccinations may represent dangers to persons with autoimmune illnesses since they contain antigens that can activate the immune system. Furthermore, due to their already overactive immune systems, some vaccines may not perform as well for people with autoimmune disorders, and some people with autoimmune diseases may have severe reactions to immunizations, producing inflammation and other symptoms. COVID-19 may not be any more hazardous to those with autoimmune illnesses than it is to the general population. The connection between COVID-19 and autoimmune disorders is complicated and under investigation. While some research implies that people with autoimmune disorders have a higher risk of severe COVID-19, others demonstrate no difference in death rates between them and the general population. There are also counterarguments that COVID-19 can induce and exacerbate autoimmune disorders, as well as worries about COVID-19 vaccine hazards for people who have autoimmune diseases. More research is required to completely understand the influence of COVID-19 on autoimmune illnesses, as well as the dangers and benefits of vaccinations for these people.

Keywords

COVID-19; SARS COV2; coronavirus; autoimmunity; molecular mimicry

Subject

Medicine and Pharmacology, Immunology and Allergy

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