Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Changes in the Incidence and Human Papillomavirus-Positive Portion of Oropharyngeal Squamous Cell Carcinoma in Hong Kong

Zigui Chen
ORCID logo ,
Amy BW Chan
ORCID logo ,
Lok Sang Kam
,
Man Hin Chan
,
Jason YK Chan
ORCID logo ,
Wai Tung Lee
,
Chit Chow
,
Siaw S Boon
ORCID logo ,
Chichao Xia
,
Brian M Lam
,
Suki Lam
,
Rita WY Ng
,
Wendy CS Ho Ho
,
Eddy WH Lam
,
Christopher KC Lai
ORCID logo ,
Paul KS Chan
* ORCID logo
Version 1 : Received: 28 November 2023 / Approved: 28 November 2023 / Online: 28 November 2023 (10:24:58 CET)

A peer-reviewed article of this Preprint also exists.

Chen, Z.; Chan, A.B.W.; Kam, L.-S.; Chan, M.-H.; Chan, J.Y.K.; Lee, W.-T.; Chow, C.; Boon, S.S.; Xia, C.; Lam, B.; Lam, S.; Ng, R.W.Y.; Ho, W.C.S.; Lam, E.W.H.; Lai, C.K.C.; Chan, P.K.S. Changes in the Incidence and Human Papillomavirus-Positive Portion of Oropharyngeal Squamous Cell Carcinoma in Hong Kong. Cancers 2024, 16, 226. Chen, Z.; Chan, A.B.W.; Kam, L.-S.; Chan, M.-H.; Chan, J.Y.K.; Lee, W.-T.; Chow, C.; Boon, S.S.; Xia, C.; Lam, B.; Lam, S.; Ng, R.W.Y.; Ho, W.C.S.; Lam, E.W.H.; Lai, C.K.C.; Chan, P.K.S. Changes in the Incidence and Human Papillomavirus-Positive Portion of Oropharyngeal Squamous Cell Carcinoma in Hong Kong. Cancers 2024, 16, 226.

Abstract

The incidence of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is rising in the West, but little is known in Asia. This study elucidated changes in the incidence and HPV-positive portion of OPSCC in Hong Kong. Data from population-based cancer registry were used to analyze the incidence of OPSCC in associate with other head and neck cancers. Archived tumour tissues were tested for HPV. From 1986 to 2020, there was a marked decrease in the incidence of nasopharyngeal and laryngeal cancers, but a persistent increase in OPSCC from 36 cases in 1986 to 116 cases in 2020. The average positive rate for high-risk HPV was 36.1% (112/310) among OPSCC diagnosed in 2010-2020. The HPV positive rate in recent years was significantly higher than earlier cases (tonsil SCC: 64.7% (55/85) in 2016-2020 vs. 40.4% (19/47) in 2010-2015, P = 0.007). Patients with HPV-positive tonsil cancers were significantly younger than those negative (mean [SD]: 58.9 [9.9] vs. 64.3 [13.3] years, P = 0.006), but no significant difference between genders. A persistent increase in the incidence of oropharyngeal cancer over the last few decades was observed in Hong Kong, which can be explained by the remarkable increase in HPV-positive tonsil cancers.

Keywords

HPV; oropharyngeal cancer; tonsil cancer; head and neck cancers; OPSCC; Hong Kong; Chinese

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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