Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Identifying the Biological Potential of Western Balkan Polypore Mushroom Species to Mitigate the Negative Effects of Global Mushroom Cultivation

Maja Kozarski
ORCID logo ,
Anita Klaus
ORCID logo ,
Bojana Špirović-Trifunović
ORCID logo ,
Srdjan Miletić
ORCID logo ,
Vesna Lazić
,
Željko Žižak
,
Jovana Vunduk
*
Version 1 : Received: 24 November 2023 / Approved: 28 November 2023 / Online: 29 November 2023 (05:29:54 CET)

A peer-reviewed article of this Preprint also exists.

Kozarski, M.; Klaus, A.; Špirović-Trifunović, B.; Miletić, S.; Lazić, V.; Žižak, Ž.; Vunduk, J. Bioprospecting of Selected Species of Polypore Fungi from the Western Balkans. Molecules 2024, 29, 314. Kozarski, M.; Klaus, A.; Špirović-Trifunović, B.; Miletić, S.; Lazić, V.; Žižak, Ž.; Vunduk, J. Bioprospecting of Selected Species of Polypore Fungi from the Western Balkans. Molecules 2024, 29, 314.

Abstract

Growing mushrooms is meeting challenges while aiming for sustainability and circularity. Wherever the producer is located, commercial strains are the same originating from several producers. Following the harvest, enormous quantities of spent mushroom substrate containing spores are disposed presenting a type of foreign material pressure on the ecosystem in the form of the loss of genetic diversity in wild mushroom populations. This challenge can be mitigated by bioprospecting local strains and using them to generate commercial inoculum. Accordingly, the mycoceutical potential of five polypore mushroom species from Serbia was evaluated: secondary metabolite composition, oxidative damage prevention, anti-tyrosinase, and anti-angiotensin converting enzyme (ACE) properties. The phenolic pattern was comparable in all samples, but the amounts of specific chemicals varied. Hydroxybenzoic acids were the primary components. All samples had varying quantities of ascorbic acid, carotene, and lycopene, and showed a pronounced inhibition of lipid peroxidation (LPx) and ability to scavenge HO•. Extracts were more potent tyrosinase inhibitors but unsuccessful when faced with ACE. Fomitopsis pinicola had the strongest anti-tumor efficacy while Ganoderma lucidum demonstrated strong selectivity in anti-tumor effect in comparison to healthy cells. The evaluated species provided a solid foundation for commercial development while keeping the local ecology in mind.

Keywords

biological activity; bioprospecting; Coriouls; Fomitopsis; Ganoderma; mushroom cultivation; oxidative damage prevention; Polypore

Subject

Chemistry and Materials Science, Food Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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