Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Omentin: An Atheroprotective Adipokine for Vascular Health

Version 1 : Received: 27 November 2023 / Approved: 28 November 2023 / Online: 28 November 2023 (07:16:38 CET)

A peer-reviewed article of this Preprint also exists.

Sena, C.M. Omentin: A Key Player in Glucose Homeostasis, Atheroprotection, and Anti-Inflammatory Potential for Cardiovascular Health in Obesity and Diabetes. Biomedicines 2024, 12, 284. Sena, C.M. Omentin: A Key Player in Glucose Homeostasis, Atheroprotection, and Anti-Inflammatory Potential for Cardiovascular Health in Obesity and Diabetes. Biomedicines 2024, 12, 284.

Abstract

Omentin is an adipokine mainly produced by visceral fat tissue, and it has two isoforms: omentin-1 and omentin-2. Omentin-1 is predominantly secreted by visceral adipose tissue, deriving specially from the stromal vascular fraction cells of white adipose tissue (WAT). Levels of omentin-1 are also expressed in other WAT depots, like epicardial adipose tissue. Omentin-1 exerts several beneficial effects in glucose homeostasis in obesity and diabetes. In addition, research has suggested that omentin may have atheroprotective (protective against the development of atherosclerosis) and anti-inflammatory effects, potentially contributing to cardiovascular health. This review highlights the potential therapeutic targets of omentin-1 in metabolic-related disorders.

Keywords

Omentin; adipokines; diabetes mellitus; endothelial dysfunction; inflammation; oxidative stress

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

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