Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Metagenomics-Based Discovery of New Hepadnaviruses

Haijing Ben
ORCID logo ,
Xuejun Wang
,
Pengxiang Yang
,
Lin Li
,
Pengxiang Liu
,
Yuxue Gao
,
Yanjun Wang
,
Yali Liu
,
Chunyang Huang
,
Dexi Chen
*
Version 1 : Received: 20 November 2023 / Approved: 20 November 2023 / Online: 21 November 2023 (09:59:58 CET)

How to cite: Ben, H.; Wang, X.; Yang, P.; Li, L.; Liu, P.; Gao, Y.; Wang, Y.; Liu, Y.; Huang, C.; Chen, D. Metagenomics-Based Discovery of New Hepadnaviruses. Preprints 2023, 2023111267. https://doi.org/10.20944/preprints202311.1267.v1 Ben, H.; Wang, X.; Yang, P.; Li, L.; Liu, P.; Gao, Y.; Wang, Y.; Liu, Y.; Huang, C.; Chen, D. Metagenomics-Based Discovery of New Hepadnaviruses. Preprints 2023, 2023111267. https://doi.org/10.20944/preprints202311.1267.v1

Abstract

Background: With continuous advances in next-generation sequencing (NGS), novel hepadnaviruses have been discovered in many species over the last 10 years. Methods: In this study, the cloud search and analysis of NGS data published in Nature by Edgar et al. was used as a basis to re-mine and reanalyze public NGS data for new hepadnaviruses. Results: Ultimately, at least 41 new species of hepadnaviruses were identified, including hepadnaviruses from the model animals hamster and mouse, frog hepadnavirus with pan-species infectivity, and diverse African cichlid hepadnaviruses that circulate within populations. Conclusions: The discovery of the new species of hepadnaviruses not only provides new clues for the study of the origin and evolution of hepadnaviruses, but also can be used to construct new hepadnavirus animal infection models, which will be helpful for the research of eradicative drugs for hepatitis B virus (HBV).

Keywords

new hepadnaviruses; hepatitis B virus; animal model; HBV cure; viral infection; metagenomics; next-generation sequencing (NGS)

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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