Version 1
: Received: 16 November 2023 / Approved: 16 November 2023 / Online: 16 November 2023 (11:29:01 CET)
How to cite:
Schmitz, C.; Alt, C.; Alt, E. Management of Knee Pain in Osteoarthritis with Orthobiologics and Corticosteroid Injection: More Questions than Answers. Preprints2023, 2023111081. https://doi.org/10.20944/preprints202311.1081.v1
Schmitz, C.; Alt, C.; Alt, E. Management of Knee Pain in Osteoarthritis with Orthobiologics and Corticosteroid Injection: More Questions than Answers. Preprints 2023, 2023111081. https://doi.org/10.20944/preprints202311.1081.v1
Schmitz, C.; Alt, C.; Alt, E. Management of Knee Pain in Osteoarthritis with Orthobiologics and Corticosteroid Injection: More Questions than Answers. Preprints2023, 2023111081. https://doi.org/10.20944/preprints202311.1081.v1
APA Style
Schmitz, C., Alt, C., & Alt, E. (2023). Management of Knee Pain in Osteoarthritis with Orthobiologics and Corticosteroid Injection: More Questions than Answers. Preprints. https://doi.org/10.20944/preprints202311.1081.v1
Chicago/Turabian Style
Schmitz, C., Christopher Alt and Eckhard Alt. 2023 "Management of Knee Pain in Osteoarthritis with Orthobiologics and Corticosteroid Injection: More Questions than Answers" Preprints. https://doi.org/10.20944/preprints202311.1081.v1
Abstract
A recent study published in Nature Medicine (Mautner et al., Nat Med 2023 Nov 2. doi: 10.1038/s41591-023-02632-w. Epub ahead of print) reported findings regarding a four-arm parallel, multicenter, single-blind, randomized, controlled clinical trial with 480 patients, aimed at comparing the therapeutic effectiveness of orthobiologic interventions against corticosteroid injections for the treatment of knee osteoarthritis (OA). The study concluded that, one-year post-treatment, all orthobiologic therapies examined were equivalent in effectiveness to each other and to corticosteroid injections. While we commend the scope and methodological rigor of the trial, the publication could be enhanced by a more comprehensive presentation of data to support the conclusions drawn. Particularly, the omission of baseline data for primary outcomes, the missing context to evaluate absolute values, the lack of discussion regarding interindividual variability, and the unexpectedly favorable results for corticosteroids that contrast the established literature, are areas that merit additional examination and insight. Here we aim to highlight these points for consideration, and advocate for the release of supplementary data to facilitate a comprehensive understanding and utilization of this rich dataset.
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
