Cardiac Amyloidosis and Valvular Heart Disease

Franz Duca; Christina Kronberger; Robin Willixhofer; Philipp Bartko; Jutta Bergler-Klein; Christian Nitsche

doi:10.20944/preprints202311.0922.v1

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preprints.org > medicine and pharmacology > cardiac and cardiovascular systems > doi: 10.20944/preprints202311.0922.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Cardiac Amyloidosis and Valvular Heart Disease

Version 1 : Received: 14 November 2023 / Approved: 14 November 2023 / Online: 14 November 2023 (11:29:57 CET)

A peer-reviewed article of this Preprint also exists.

Duca, F.; Kronberger, C.; Willixhofer, R.; Bartko, P.E.; Bergler-Klein, J.; Nitsche, C. Cardiac Amyloidosis and Valvular Heart Disease. J. Clin. Med. 2024, 13, 221. Duca, F.; Kronberger, C.; Willixhofer, R.; Bartko, P.E.; Bergler-Klein, J.; Nitsche, C. Cardiac Amyloidosis and Valvular Heart Disease. J. Clin. Med. 2024, 13, 221.

Abstract

Growing interest has accrued in the co-existence of cardiac amyloidosis and valvular heart disease. Amyloid infiltration from either transthyretin (ATTR) or light chain (AL) origin may affect any structure of the heart, including the valves. Recent literature has mainly focused on aortic stenosis and cardiac amyloidosis, improving our understanding of epidemiology, diagnosis, treatment and prognosis of this dual pathology. Even though of high clinical relevance, data on mitral/tricuspid regurgitation and cardiac amyloidosis is rather scarce and mostly limited to case reports and small cases series. It is the aim of this review article to summarize the current evidence of concomitant valvular heart disease and cardiac amyloidosis including epidemiology, diagnostic approaches, screening possibilities, therapeutic management, and prognostic implications.

Keywords

aortic stenosis; mitral regurgitation; tricuspid regurgitation; AL; ATTR

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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