Version 1
: Received: 13 November 2023 / Approved: 14 November 2023 / Online: 14 November 2023 (12:02:00 CET)
How to cite:
Alsabhan, J.F.; Almalag, H.M.; Alnuaim, L.A.; Albaker, A.B. Impact of Selective Serotonin Reuptake Inhibitor on Male Infertility: A Retrospective Pilot Study. Preprints2023, 2023110910. https://doi.org/10.20944/preprints202311.0910.v1
Alsabhan, J.F.; Almalag, H.M.; Alnuaim, L.A.; Albaker, A.B. Impact of Selective Serotonin Reuptake Inhibitor on Male Infertility: A Retrospective Pilot Study. Preprints 2023, 2023110910. https://doi.org/10.20944/preprints202311.0910.v1
Alsabhan, J.F.; Almalag, H.M.; Alnuaim, L.A.; Albaker, A.B. Impact of Selective Serotonin Reuptake Inhibitor on Male Infertility: A Retrospective Pilot Study. Preprints2023, 2023110910. https://doi.org/10.20944/preprints202311.0910.v1
APA Style
Alsabhan, J.F., Almalag, H.M., Alnuaim, L.A., & Albaker, A.B. (2023). Impact of Selective Serotonin Reuptake Inhibitor on Male Infertility: A Retrospective Pilot Study. Preprints. https://doi.org/10.20944/preprints202311.0910.v1
Chicago/Turabian Style
Alsabhan, J.F., Lulu A. Alnuaim and Awatif B. Albaker. 2023 "Impact of Selective Serotonin Reuptake Inhibitor on Male Infertility: A Retrospective Pilot Study" Preprints. https://doi.org/10.20944/preprints202311.0910.v1
Abstract
Abstract:
Background: Multiple factors cause male infertility. To date, there is insufficient data to support claims that selective serotonin reuptake inhibitors (SSRIs) affect the effectiveness of infertility treatments or decrease fertility. This study aimed to determine the feasibility of male infertility caused by SSRI antidepressants.
Methods: This study was a retrospective chart review of Saudi males who are currently or previously treated with SSRIs and attended infertility clinics in KSMC. Medical records of men in an infertility clinic were reviewed to screen the quality of sperm parameters in patients taking SSRIs.
Results: In total, 299 men were identified, of whom 29 (9.6%) were exposed to SSRIs, while 270 (90.4%) did not receive SSRIs, defined as the control infertile group. There was a significant difference between the non-SSRI group (34.2 ± 6.9 years) and SSRI group (41.5 ± 3.2 years), p < 0.001. Regarding sperm analysis and the use of SSRIs, the impact of SSRIs use showed no significant differences in sperm liquefaction (p = 0.1), motility (p = 0.17), viscosity (p = 0.16), and sperm count (p = 0.069) with escitalopram, fluoxetine, and paroxetine use.
Conclusion: SSRI medication use and the likelihood of developing infertility require larger prospective trials.
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
