Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

High Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study

Celia Maria Cassaro Strunz
* ,
Whady Hueb
,
Paulo Cury Rezende
,
Sabrina Pacheco do Amaral Vendramini
ORCID logo ,
Arthur Cicupira Rodrigues de Assis
,
Alessandra Roggerio
,
Maria Stanislavovna Tairova
,
Marcela Francisca Silva
,
Senili Avila Oliveira
,
Gyovanna de Cassia Agreste Kisser Kisser
,
Roberto Kalil Filho
Version 1 : Received: 13 November 2023 / Approved: 13 November 2023 / Online: 13 November 2023 (13:40:44 CET)

A peer-reviewed article of this Preprint also exists.

Strunz, C.M.C.; Hueb, W.; Rezende, P.C.; Vendramini, S.P.A.; Assis, A.C.R.; Roggerio, A.; Tairova, M.S.; Silva, M.F.; Oliveira, S.A.; Kisser, G.C.A.; Kalil Filho, R. High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study. Int. J. Mol. Sci. 2023, 24, 17286. Strunz, C.M.C.; Hueb, W.; Rezende, P.C.; Vendramini, S.P.A.; Assis, A.C.R.; Roggerio, A.; Tairova, M.S.; Silva, M.F.; Oliveira, S.A.; Kisser, G.C.A.; Kalil Filho, R. High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study. Int. J. Mol. Sci. 2023, 24, 17286.

Abstract

Numerous studies were published suggesting that troponin level is related to adverse outcomes in chronic cardiac and non-cardiac conditions. Our study investigated whether troponin levels gathered from an unselected blood sample taken during outpatient care are associated with adverse outcomes in a population with stable coronary artery disease. In a cohort of 949 patients with stable coronary artery disease, average age of 67.5 ± 9.5 years, 69.5% male, 52.1% diabetics, 51.6% with previous myocardial infarction, 57.9% with triple-vessel disease, 21.7% of patients encountered new events during an average period of monitoring of 2.07 ± 0.81 years. Troponin I/99th percentile categorized into tertiles emerged as an independent predictor of death and combined events risk (hazard ratio: 2.02 (1.13-3.60), p=0.017; 2.30 (1.37-3.88, p=0.002, respectively). A troponin ratio > 0.24 was able to identify 53.3% of patients at risk of death and heart failure hospitalization. In patients with stable coronary artery disease and adherent to treatment, troponin level is independently associated with death and heart failure hospitalization in a medium-term follow up.

Keywords

high sensitivity troponin I; cTnI/99th tertiles; stable coronary artery disease; cardiovascular events

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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