PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?
Version 1
: Received: 8 November 2023 / Approved: 9 November 2023 / Online: 9 November 2023 (10:06:30 CET)
How to cite:
Zhanina, M. Y.; Druzhkova, T. A.; Ierusalimsky, N. V.; Vladimirova, E. E.; Eremina, N. N.; Guekht, A. B.; Gulyaeva, N. V. Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?. Preprints2023, 2023110625. https://doi.org/10.20944/preprints202311.0625.v1
Zhanina, M. Y.; Druzhkova, T. A.; Ierusalimsky, N. V.; Vladimirova, E. E.; Eremina, N. N.; Guekht, A. B.; Gulyaeva, N. V. Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?. Preprints 2023, 2023110625. https://doi.org/10.20944/preprints202311.0625.v1
Zhanina, M. Y.; Druzhkova, T. A.; Ierusalimsky, N. V.; Vladimirova, E. E.; Eremina, N. N.; Guekht, A. B.; Gulyaeva, N. V. Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?. Preprints2023, 2023110625. https://doi.org/10.20944/preprints202311.0625.v1
APA Style
Zhanina, M. Y., Druzhkova, T. A., Ierusalimsky, N. V., Vladimirova, E. E., Eremina, N. N., Guekht, A. B., & Gulyaeva, N. V. (2023). Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?. Preprints. https://doi.org/10.20944/preprints202311.0625.v1
Chicago/Turabian Style
Zhanina, M. Y., Alla B. Guekht and Natalia V. Gulyaeva. 2023 "Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?" Preprints. https://doi.org/10.20944/preprints202311.0625.v1
Abstract
Post-stroke depressive disorders (PSD) and post-stroke cognitive impairments (PCI) are frequent consequences of ischemic stroke (IS). The study was focused on exploring possible associations between relative volumes of cortical and limbic brain structures during the acute period of IS, and changes in biochemical indices of hypothalamic-pituitary-adrenal, sympathoadrenal medullary and inflammatory systems, with the development of PSD or PCI after mild or moderate IS. Patients developing PSD later on had significantly smaller relative volumes of the hippocampus, entorhinal cortex, and temporal pole versus patients without depressive symptoms. PCI development was associated with significantly smaller volumes of temporal pole and supramarginal gyrus versus patients without cognitive changes. Multiple logistic regression analysis showed higher likelihood of developing PSD in patients with smaller temporal pole volume (β0=10.9; β=-4.27; p=0.04) and increased salivary α-amylase activity (β0=-3.55; β=2.68e-05; p=0.02,). PCI likelihood was higher in patients with smaller supramarginal gyrus volume (β0=3.41; β=-0.99; p=0.047), smaller temporal pole volume (β0=3.41; β=-3.12; p=0. 06), and increased hair cortisol concentration at admission (index of accumulated stress load within a month before IS; β0=3.41; β=-0.05; p=0.08). The data support the hypothesis suggesting predisposition to PSD and PCI and multi hit scenarios of their pathogenesis with IS providing a final hit.
Keywords
ischemic stroke; MRI; morphometry; post-stroke cognitive impairment, post-stroke depressive disorder; cortisol; α-amylase; interleukin-6; multiple hit hypothesis; hypothalamic-pituitary-adrenal axis; sympathoadrenal system
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
