Lin, X.; Shi, Y.; Zhan, Y.; Xing, Y.; Li, Y.; Zhou, Z.; Chen, G. Advances of Protein Palmitoylation in Tumor Cell Deaths. Cancers2023, 15, 5503.
Lin, X.; Shi, Y.; Zhan, Y.; Xing, Y.; Li, Y.; Zhou, Z.; Chen, G. Advances of Protein Palmitoylation in Tumor Cell Deaths. Cancers 2023, 15, 5503.
Lin, X.; Shi, Y.; Zhan, Y.; Xing, Y.; Li, Y.; Zhou, Z.; Chen, G. Advances of Protein Palmitoylation in Tumor Cell Deaths. Cancers2023, 15, 5503.
Lin, X.; Shi, Y.; Zhan, Y.; Xing, Y.; Li, Y.; Zhou, Z.; Chen, G. Advances of Protein Palmitoylation in Tumor Cell Deaths. Cancers 2023, 15, 5503.
Abstract
In this comprehensive survey, we delve into the multifaceted role of palmitoylation across vari-ous cell death modalities in the oncological context. From its intricate correlations with tumor-igenesis, steered by the DHHC family, to the counter-process of depalmitoylation mediated by enzymes like PPT1. Innovations in detection methodologies have paralleled our growing under-standing, transitioning from rudimentary techniques to sophisticated modern methods. Central to our discourse are agents like GNS561 and DC661, promising heralds in palmitoylation-targeted cancer therapy. Collectively, this review accentuates palmitoylation's transformative potential in oncology, foreshadowing groundbreaking therapeutic strategies and deepening our molecular comprehension of cancer dynamics.
Keywords
protein palmitoylation; apoptosis; autophagy; ferroptosis; pyroptosis
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
