Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

From Mother to Infant, from Placenta to Gut: Understanding Varied Microbiome Profiles in Neonates

Version 1 : Received: 3 November 2023 / Approved: 6 November 2023 / Online: 6 November 2023 (08:10:26 CET)

A peer-reviewed article of this Preprint also exists.

Cheddadi, R.; Yeramilli, V.; Martin, C. From Mother to Infant, from Placenta to Gut: Understanding Varied Microbiome Profiles in Neonates. Metabolites 2023, 13, 1184. Cheddadi, R.; Yeramilli, V.; Martin, C. From Mother to Infant, from Placenta to Gut: Understanding Varied Microbiome Profiles in Neonates. Metabolites 2023, 13, 1184.

Abstract

The field of human microbiome and gut microbial diversity research has witnessed a profound transformation, driven by advances in omics technologies. These advancements have unveiled essential connections between microbiome alterations and severe conditions, spurring the development of new frameworks through epidemiological studies. Traditionally, each individual was thought to harbor unique microbial communities acquired early in life, but recent research challenges this belief. The neonatal microbiome's onset, influenced by factors like delivery mode and maternal health, remains a subject of intense debate, hinting at potential intrauterine microbial processes. In-depth research reveals associations between microbiome profiles and specific health outcomes, ranging from obesity to neurodevelopmental disorders. Understanding these diverse microbiome profiles is essential for unraveling the intricate relationships between the microbiome and health outcomes.

Keywords

Neonatal microbiome; Maternal effect; Placental Microbiome; intra-uterine development

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

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