PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Does the Prevalence of Subclinical Coronary Atherosclerosis Increase in Primary Hyperparathyroidism; Coronary Flow Reserve and Plasma Aterogenic Index in Patients with Primary Hyperparathyroidism
Version 1
: Received: 31 October 2023 / Approved: 1 November 2023 / Online: 1 November 2023 (13:16:23 CET)
How to cite:
Cetinkaya, Z.; Kelesoğlu, S.; Gokay, F.; Yilmaz, Y. Does the Prevalence of Subclinical Coronary Atherosclerosis Increase in Primary Hyperparathyroidism; Coronary Flow Reserve and Plasma Aterogenic Index in Patients with Primary Hyperparathyroidism. Preprints2023, 2023110068. https://doi.org/10.20944/preprints202311.0068.v1
Cetinkaya, Z.; Kelesoğlu, S.; Gokay, F.; Yilmaz, Y. Does the Prevalence of Subclinical Coronary Atherosclerosis Increase in Primary Hyperparathyroidism; Coronary Flow Reserve and Plasma Aterogenic Index in Patients with Primary Hyperparathyroidism. Preprints 2023, 2023110068. https://doi.org/10.20944/preprints202311.0068.v1
Cetinkaya, Z.; Kelesoğlu, S.; Gokay, F.; Yilmaz, Y. Does the Prevalence of Subclinical Coronary Atherosclerosis Increase in Primary Hyperparathyroidism; Coronary Flow Reserve and Plasma Aterogenic Index in Patients with Primary Hyperparathyroidism. Preprints2023, 2023110068. https://doi.org/10.20944/preprints202311.0068.v1
APA Style
Cetinkaya, Z., Kelesoğlu, S., Gokay, F., & Yilmaz, Y. (2023). Does the Prevalence of Subclinical Coronary Atherosclerosis Increase in Primary Hyperparathyroidism; Coronary Flow Reserve and Plasma Aterogenic Index in Patients with Primary Hyperparathyroidism. Preprints. https://doi.org/10.20944/preprints202311.0068.v1
Chicago/Turabian Style
Cetinkaya, Z., Ferhat Gokay and Yucel Yilmaz. 2023 "Does the Prevalence of Subclinical Coronary Atherosclerosis Increase in Primary Hyperparathyroidism; Coronary Flow Reserve and Plasma Aterogenic Index in Patients with Primary Hyperparathyroidism" Preprints. https://doi.org/10.20944/preprints202311.0068.v1
Abstract
Introduction: The coronary flow reserve (CFR) is a sign of early-stage coronary artery disease (CAD). Plasma atherogenic index (PAI) is related to atherosclerosis and cardiovascular mortality. Therefore, our aim was to determine CFR and PAI in patients with primary hyperparathyroidism (PHPT) and investigate whether PAI can be used in the detection of early-stage CAD.
Material and Methods: The sample was comprised of 44 patients with PTHT and 33 healthy volunteers. We defined CFR as the ratio of the hyperemic diastolic peak velocity to the baseline diastolic peak velocity. PAI values were calculated with the formula of log 10 triglyceride (TRG) / high-density lipoprotein (HDL).
Result: The comparison of the groups for PAI and CFR demonstrated that PAI levels were significantly higher while CFR levels were significantly lower in the PTHT patients (p<0.01, p=0.01, respectively). The correlation analysis revealed that CFR was negatively correlated with PAI and TRG (PAI- p<0.0001 r=-0.537).The multivariate logistic regression analysis showed that only a high PAI level (OR: 151.6, 95% confidence interval (CI): 4.1-5480, p=0.006) was an independent predictor of reduction in CFR in PHPT patients.
Conclusion: Overall, we found an independent correlation between PAI and CFR values. Hence, PAI may be useful in identifying PHPT patients facing a high risk of adverse cardiovascular events and may also allow early diagnosis of subclinical atherosclerosis.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
