Irún, P.; Carrera-Lasfuentes, P.; Sánchez-Luengo, M.; Belio, Ú.; Domper-Arnal, M.J.; Higuera, G.A.; Hawkins, M.; de la Rosa, X.; Lanas, A. Pharmacokinetics and Changes in Lipid Mediator Profiling after Consumption of Specialized Pro-Resolving Lipid-Mediator-Enriched Marine Oil in Healthy Subjects. Int. J. Mol. Sci.2023, 24, 16143.
Irún, P.; Carrera-Lasfuentes, P.; Sánchez-Luengo, M.; Belio, Ú.; Domper-Arnal, M.J.; Higuera, G.A.; Hawkins, M.; de la Rosa, X.; Lanas, A. Pharmacokinetics and Changes in Lipid Mediator Profiling after Consumption of Specialized Pro-Resolving Lipid-Mediator-Enriched Marine Oil in Healthy Subjects. Int. J. Mol. Sci. 2023, 24, 16143.
Irún, P.; Carrera-Lasfuentes, P.; Sánchez-Luengo, M.; Belio, Ú.; Domper-Arnal, M.J.; Higuera, G.A.; Hawkins, M.; de la Rosa, X.; Lanas, A. Pharmacokinetics and Changes in Lipid Mediator Profiling after Consumption of Specialized Pro-Resolving Lipid-Mediator-Enriched Marine Oil in Healthy Subjects. Int. J. Mol. Sci.2023, 24, 16143.
Irún, P.; Carrera-Lasfuentes, P.; Sánchez-Luengo, M.; Belio, Ú.; Domper-Arnal, M.J.; Higuera, G.A.; Hawkins, M.; de la Rosa, X.; Lanas, A. Pharmacokinetics and Changes in Lipid Mediator Profiling after Consumption of Specialized Pro-Resolving Lipid-Mediator-Enriched Marine Oil in Healthy Subjects. Int. J. Mol. Sci. 2023, 24, 16143.
Abstract
Omega-3 polyunsaturated fatty acids (PUFA) play a pivotal role in health, wellbeing, and inflammatory diseases in humans. Lack of omega-3 consumption is associated with diseases. Specialized Pro-resolving Mediators (SPM) are produced from Omega-3-PUFAs and accelerate resolution of inflammation. They are classified as resolvins, maresins, protectins, and lipoxins. SPMs actions in resolution consist in limiting neutrophilic infiltration, promote the clearance of apoptotic cell and cellular debris, enhancing efferocytosis and phagocytosis, counter regulate the production of pro-inflammatory mediators such as chemokines and cytokines, and promote pro-resolving macrophage phenotype. We identified temporal plasma and serum increases of SPMs after 6 g of oral supplementation of SPM-enriched emulsion in ten healthy subjects. We also described temporal increases of omega-3, as well as pharmacokinetics fundamentals in plasma and serum using LC-MS/MS lipid profiling. These results provide evidence of temporal increases of SPMs that together support the idea that given oral supplementation is a good source of essential bioactive SPMs.
Medicine and Pharmacology, Complementary and Alternative Medicine
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