Pawar, T.J.; Ventura-Hernández, K.I.; Ramos-Morales, F.R.; Olivares-Romero, J.L. Chiral Hydroxamic Acid Ligands in the Asymmetric Synthesis of Natural Products. Chemistry2023, 5, 2700-2712.
Pawar, T.J.; Ventura-Hernández, K.I.; Ramos-Morales, F.R.; Olivares-Romero, J.L. Chiral Hydroxamic Acid Ligands in the Asymmetric Synthesis of Natural Products. Chemistry 2023, 5, 2700-2712.
Pawar, T.J.; Ventura-Hernández, K.I.; Ramos-Morales, F.R.; Olivares-Romero, J.L. Chiral Hydroxamic Acid Ligands in the Asymmetric Synthesis of Natural Products. Chemistry2023, 5, 2700-2712.
Pawar, T.J.; Ventura-Hernández, K.I.; Ramos-Morales, F.R.; Olivares-Romero, J.L. Chiral Hydroxamic Acid Ligands in the Asymmetric Synthesis of Natural Products. Chemistry 2023, 5, 2700-2712.
Abstract
Chiral hydroxamic acid (HA) and bis-hydroxamic acid (BHA) ligands have made significant contributions to the field of asymmetric synthesis, particularly in the synthesis of natural products. These ligands possess unique molecular structures that allow for exceptional stereochemical control, leading to their widespread use in catalytic systems. This review highlights the advancements made in asymmetric synthesis using chiral hydroxamic acid and bis-hydroxamic acid ligands and their impact on the synthesis of complex natural products. The discussion encompasses their role in enantioselective C-C bond formation, the functionalization of C-H bonds, asymmetric transformations involving heteroatoms, and their application in the total synthesis of natural products. The versatility and efficiency of chiral hydroxamic acid ligands and bis-hydroxamic acid ligands make them invaluable tools for synthetic chemists working towards the efficient and selective synthesis of natural products. This review provides a comprehensive overview of their contributions, showcasing their potential to expand the boundaries of chemical synthesis and access the diverse array of natural product scaffolds.
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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