Version 1
: Received: 7 October 2023 / Approved: 8 October 2023 / Online: 8 October 2023 (08:26:48 CEST)
How to cite:
Bafail, R.; Samman, W.; Alsulaimany, M.; Aljohani, A. Pharmacological Evaluation and Molecular Docking of Novel Synthesized Pyrazolopyrimidine Derivatives. Preprints2023, 2023100436. https://doi.org/10.20944/preprints202310.0436.v1
Bafail, R.; Samman, W.; Alsulaimany, M.; Aljohani, A. Pharmacological Evaluation and Molecular Docking of Novel Synthesized Pyrazolopyrimidine Derivatives. Preprints 2023, 2023100436. https://doi.org/10.20944/preprints202310.0436.v1
Bafail, R.; Samman, W.; Alsulaimany, M.; Aljohani, A. Pharmacological Evaluation and Molecular Docking of Novel Synthesized Pyrazolopyrimidine Derivatives. Preprints2023, 2023100436. https://doi.org/10.20944/preprints202310.0436.v1
APA Style
Bafail, R., Samman, W., Alsulaimany, M., & Aljohani, A. (2023). Pharmacological Evaluation and Molecular Docking of Novel Synthesized Pyrazolopyrimidine Derivatives. Preprints. https://doi.org/10.20944/preprints202310.0436.v1
Chicago/Turabian Style
Bafail, R., Marwa Alsulaimany and Ahmed Aljohani. 2023 "Pharmacological Evaluation and Molecular Docking of Novel Synthesized Pyrazolopyrimidine Derivatives" Preprints. https://doi.org/10.20944/preprints202310.0436.v1
Abstract
A series of pyrazolopyrimidines derivatives 4– 11 were synthesized using 1-(6-(3-methoxyphenyl)-4-methylpyridazin-3-yl)-1H-pyrazolo [3,4-d] pyrimidin-4-amine 3 as a starting material. The detailed synthesis, structure assignments of the novel compounds based on chemical and spectroscopic evidence, spectroscopic data, pharmacological properties and molecular docking are reported. The pharmacological evaluation illustrated that many of these compounds have good analgesic, anti-inflammatory and antimicrobial activities.
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
