Closca, R.-M.; Nicoara, A.; Rakitovan, M.; Mot, I.C.; Baderca, F. Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge. Diagnostics 2023, 13, 3513, doi:10.3390/diagnostics13233513.
Closca, R.-M.; Nicoara, A.; Rakitovan, M.; Mot, I.C.; Baderca, F. Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge. Diagnostics 2023, 13, 3513, doi:10.3390/diagnostics13233513.
Closca, R.-M.; Nicoara, A.; Rakitovan, M.; Mot, I.C.; Baderca, F. Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge. Diagnostics 2023, 13, 3513, doi:10.3390/diagnostics13233513.
Closca, R.-M.; Nicoara, A.; Rakitovan, M.; Mot, I.C.; Baderca, F. Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge. Diagnostics 2023, 13, 3513, doi:10.3390/diagnostics13233513.
Abstract
The metastatic disease is a complex and sequential process that involves the migration of tumor cells from the primary site to distant areas. This metastatic pathway is not always predictable. Therefore, this paper presents three rare cases of unusual metastases, due to their primary site: two metastases of a clear cell renal cell carcinoma, one gingival and one nasal, as well as a mandibular metastasis of a hepatocellular carcinoma. In all cases, an incisional biopsy was performed in order to sign out the diagnosis. After microscopical examination of morphological Hematoxylin and Eosin stained slides, for all cases, immunohistochemical reactions were performed to support the primary tumor site. Two cases had a previous histopathological diagnosis of a primary tumor, while for the third case, the metastatic lesion represented the first manifestation of the neoplastic disease, with an unfavorable prognosis.
Keywords
Head and neck, unusual metastases, immunohistochemistry, renal clear cell carcinoma, hepatocellular carcinoma
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
