Version 1
: Received: 30 September 2023 / Approved: 2 October 2023 / Online: 2 October 2023 (11:06:33 CEST)
Version 2
: Received: 3 October 2023 / Approved: 4 October 2023 / Online: 4 October 2023 (07:58:34 CEST)
How to cite:
Semerdzhieva, N.E.; Tsakova, A.D.; Hristova, J.; Lozanov, V.S.; Loznova, V.V.; Gospodinova, M.; Dimitrov, S.I.; Atanasov, P.Y.; Chaneva, M. Sex-specific Impact of 17β-estradiol and Testosterone Levels on Inflammation and Injury in Acute Myocardial Infarction. Preprints2023, 2023100059. https://doi.org/10.20944/preprints202310.0059.v2
Semerdzhieva, N.E.; Tsakova, A.D.; Hristova, J.; Lozanov, V.S.; Loznova, V.V.; Gospodinova, M.; Dimitrov, S.I.; Atanasov, P.Y.; Chaneva, M. Sex-specific Impact of 17β-estradiol and Testosterone Levels on Inflammation and Injury in Acute Myocardial Infarction. Preprints 2023, 2023100059. https://doi.org/10.20944/preprints202310.0059.v2
Semerdzhieva, N.E.; Tsakova, A.D.; Hristova, J.; Lozanov, V.S.; Loznova, V.V.; Gospodinova, M.; Dimitrov, S.I.; Atanasov, P.Y.; Chaneva, M. Sex-specific Impact of 17β-estradiol and Testosterone Levels on Inflammation and Injury in Acute Myocardial Infarction. Preprints2023, 2023100059. https://doi.org/10.20944/preprints202310.0059.v2
APA Style
Semerdzhieva, N.E., Tsakova, A.D., Hristova, J., Lozanov, V.S., Loznova, V.V., Gospodinova, M., Dimitrov, S.I., Atanasov, P.Y., & Chaneva, M. (2023). Sex-specific Impact of 17β-estradiol and Testosterone Levels on Inflammation and Injury in Acute Myocardial Infarction. Preprints. https://doi.org/10.20944/preprints202310.0059.v2
Chicago/Turabian Style
Semerdzhieva, N.E., Petar Yordanov Atanasov and Maria Chaneva. 2023 "Sex-specific Impact of 17β-estradiol and Testosterone Levels on Inflammation and Injury in Acute Myocardial Infarction" Preprints. https://doi.org/10.20944/preprints202310.0059.v2
Abstract
Estrogens play a protective role during early life stages. However, endogenous 17β-estradiol (E2) can accelerate atherosclerosis progression in low-grade inflammatory conditions like established atherosclerosis. Our single-center cohort study assessed sex-specific associations of gonadal hormones with oxidative stress, inflammation, and myocardial injury markers in 111 patients (37% women) diagnosed with acute myocardial infarction (MI) between July 2011 and December 2013. Blood samples were collected within 48 hours of symptom onset, and we measured sex steroids (E2, total testosterone [T]), oxidized low-density lipoproteins, high-sensitive C-reactive protein (CRP), white blood cell counts (WBC), and cardiac enzymes (creatine kinase [CK], the CK Muscle-Brain fraction [CK-MB], and high-sensitive troponin T [hsTnT]). The SYNTAX score gauged coronary disease severity from coronary angiography results. In men with acute MI, peak cardiac enzyme levels were predicted by post-percutaneous coronary intervention (PCI) E2 plasma levels (OR 1.011, p=0.047 - CK; OR 1.018, p=0.013 - CK- MB; OR 1.019, p=0.005 - TnT), peak WBC count (OR 1.487, p=0.015 - CK ; OR 1,709, p=0,005 - CK- MB; OR 1.391, p=0.012 - TnT), and peak CRP plasma levels (OR 1.040, p=0.033 - CK; OR 1.024, p=0.029 - CK-MB; OR 1.063, p=0.006 - TnT). T levels and E2/T ratio were associated with post-PCI CRP in these men (OR 0.980, p = 0.024 - T, OR 1.010, p = 0.076 - CRP). For women, peak WBC was a marker of highest testosterone (OR 1.348, p = 0.062), and only WBC was a significant indicator of myocardial injury extent (OR 1.426, p=0.039 - CK; OR 1.384, p=0.036 - CK-MB; OR 1.299, p=0.048 - TnT). During acute MI, elevated endogenous estradiol levels correlate with myocardial necrosis severity in men, while in women, increased leukocyte levels indicate acute myocardial damage. Elevated plasma T is associated with increased WBC in women. In men, post-PCI plasma CRP specifically indicates endogenous T levels and E2/T ratio during the acute phase.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
4 October 2023
Commenter:
Niya Semerdzhieva
Commenter's Conflict of Interests:
Author
Comment:
The Preprint.org has generated wrong version of my manuscript the first time I had tried to downlad the manuscript "Sex-specific Impact of 17β-estradiol and Testosterone Levels on Inflammation and Injury in Acute Myocardial Infarction".
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Commenter: Niya Semerdzhieva
Commenter's Conflict of Interests: Author