Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review

Lavinia Capossela
* ,
Serena Ferretti
ORCID logo ,
Silvia D'Alonzo
,
Lorenzo Di Sarno
,
Valeria Pansini
,
Antonietta Curatola
,
Antonio Chiaretti
,
Antonio Gatto
ORCID logo
Version 1 : Received: 27 September 2023 / Approved: 14 October 2023 / Online: 14 October 2023 (18:40:46 CEST)

A peer-reviewed article of this Preprint also exists.

Capossela, L.; Ferretti, S.; D’Alonzo, S.; Di Sarno, L.; Pansini, V.; Curatola, A.; Chiaretti, A.; Gatto, A. Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review. Biology 2023, 12, 1395. Capossela, L.; Ferretti, S.; D’Alonzo, S.; Di Sarno, L.; Pansini, V.; Curatola, A.; Chiaretti, A.; Gatto, A. Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review. Biology 2023, 12, 1395.

Abstract

Intense alterations of mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and represent an important cause of morbidity and decreased quality of life. These disor-ders have traditionally been defined as renal osteodystrophy and classified based on bone biop-sy, but due to a lack of bone biopsy data and validated radiological methods to evaluate bone morphology in children, it has been difficult to adequately evaluate renal osteodystrophy in pe-diatric CKD. This has led to suboptimal management of bone disorders in children. CKD-mineral and bone disorder (CKD-MBD) is a new term used to describe a systemic disorder of mineral and bone metabolism as a result of CKD. CKD-MBD is a triad of biochemical imbalances of cal-cium, phosphate, parathyroid hormone and vitamin D, bone abnormalities and soft tissue calci-fication. This literature review aims to explore the pathogenesis, diagnostic approach, and treat-ment of CKD-MBD in children and the specific consequences of renal osteodystrophy on growing skeleton, with a specific focus on the biological basis of this peculiar condition.

Keywords

bone; disease; renal; children; osteodystrophy

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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