Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Neuropsychiatric Systemic Lupus Erythematosus: Antibodies Involved, Clinical Characteristics and Treatment

Version 1 : Received: 28 September 2023 / Approved: 28 September 2023 / Online: 28 September 2023 (13:37:20 CEST)

How to cite: Gopaul, D.A.; Vaillant, A. Neuropsychiatric Systemic Lupus Erythematosus: Antibodies Involved, Clinical Characteristics and Treatment. Preprints 2023, 2023092018. https://doi.org/10.20944/preprints202309.2018.v1 Gopaul, D.A.; Vaillant, A. Neuropsychiatric Systemic Lupus Erythematosus: Antibodies Involved, Clinical Characteristics and Treatment. Preprints 2023, 2023092018. https://doi.org/10.20944/preprints202309.2018.v1

Abstract

Systemic lupus erythematosus (SLE) is a chronic idiopathic autoimmune disease affecting various organs. Patients with SLE also present numerous neuropsychiatric manifestations. These neuro-psychiatric manifestations are referred to as neuropsychiatric systemic lupus erythematosus (NPSLE). Neuropsychiatric involvement in patients with SLE was first mentioned by Kaposi more than 100 years ago and is a generic term that refers to neurological and psychiatric symp-toms resulting directly from or as a complication of SLE. NPSLE affects both the CNS and PNS and can manifest as various symptoms, such as cognitive dysfunction, organic brain syndromes, delirium, seizures, headache, and psychosis. NPSLE was previously referred to as ‘lupus cerebri-tis’ or lupus sclerosis. However, these terms are no longer recommended because there is no de-finitive pathological cause for the neuropsychiatric manifestations of SLE.[2]

Keywords

Systemic Lupus Erythematosus; steroids; psychosis; DSM-V

Subject

Medicine and Pharmacology, Clinical Medicine

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