Qu, L.; Liu, C.; Cao, Y.; Shi, J.; Yin, K.; Liu, W. Differences and Changes in Cerebellar Functional Connectivity of Parkinson’s Patients with Visual Hallucinations. Brain Sci.2023, 13, 1458.
Qu, L.; Liu, C.; Cao, Y.; Shi, J.; Yin, K.; Liu, W. Differences and Changes in Cerebellar Functional Connectivity of Parkinson’s Patients with Visual Hallucinations. Brain Sci. 2023, 13, 1458.
Qu, L.; Liu, C.; Cao, Y.; Shi, J.; Yin, K.; Liu, W. Differences and Changes in Cerebellar Functional Connectivity of Parkinson’s Patients with Visual Hallucinations. Brain Sci.2023, 13, 1458.
Qu, L.; Liu, C.; Cao, Y.; Shi, J.; Yin, K.; Liu, W. Differences and Changes in Cerebellar Functional Connectivity of Parkinson’s Patients with Visual Hallucinations. Brain Sci. 2023, 13, 1458.
Abstract
Recent studies have discovered that functional connections are impaired in patients with Parkinson's disease (PD) accompanied by hallucinations(PD-H), even at the preclinical stage. The cerebellum has been implicated as playing a role in cognitive processes. However, the functional connectivity (FC) between cognitive sub-regions of the cerebellum of PD patients with hallucinations needs to be further clarified. Resting-state functional magnetic resonance imaging (rs-fMRI) data from three groups (17 PD-H, 13 no hallucinations accompanying the (PD-NH), and 26 healthy controls (HC) ) was collected in this study to explore the role of cerebellar FC changes in the cognitive performance. Additionally, we define cerebellar FC as a training feature for classifying all subjects using Support Vector Machine(SVM). We found that PD-H patients' cerebellum(Vermis_4_5 ) FC had increased within the left side of the precuneus(PCUN) compared to HC, cerebellum(Vermis_1_2) had increased within bilateral opercular part of the inferior frontal gyrus(IFGoprec) and triangular part of the inferior frontal gyrus(IFCtriang), left side of postcentral gyrus(PoCG), Inferior parietal lobe(IPL), and PCUNs compared to PD-NH. In the training results of machine learning, cerebellar FC has also been proven to be an effective biomarker feature, with a recognition rate of over 90% for PD-H. These findings indicate that cortico-cerebellar FC in PD-H and PD-NH patients were significantly disrupted with different distributions. The proposed pipeline offers a promising low-cost alternative for the diagnosis of preclinical PD-H and can be useful for other degenerative brain disorders.
Medicine and Pharmacology, Neuroscience and Neurology
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