Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

A Systematic Review of Microparticulate Air Pollution in Polycystic Ovary Syndrome

Version 1 : Received: 20 September 2023 / Approved: 20 September 2023 / Online: 21 September 2023 (12:12:52 CEST)

How to cite: Stegehuis, N.; Kotsirilos, V.; Parker, J. A Systematic Review of Microparticulate Air Pollution in Polycystic Ovary Syndrome. Preprints 2023, 2023091406. https://doi.org/10.20944/preprints202309.1406.v1 Stegehuis, N.; Kotsirilos, V.; Parker, J. A Systematic Review of Microparticulate Air Pollution in Polycystic Ovary Syndrome. Preprints 2023, 2023091406. https://doi.org/10.20944/preprints202309.1406.v1

Abstract

Polycystic ovary syndrome (PCOS) is increasingly being viewed as an evolutionary mismatch disorder that manifests in women after exposure to a range of lifestyle and environmental factors. Although there is ongoing debate regarding the pathogenesis, international guidelines recommend lifestyle treatment, with diet and exercise, as the first line of management in all women with PCOS. In addition, accumulating evidence suggests that environmental factors such as endocrine disrupting chemicals (EDC) may be involved in the pathogenesis of PCOS due to their known hormonal and metabolic effects. As a result, international professional bodies have recommended that all pregnant women be advised of the risks of EDC and that education programs be developed to inform health professionals. Microparticulate air pollution (MAP) is also a significant environmental exposure that has been associated with a variety of chronic diseases, including PCOS. We performed a systematic review of studies examining the relationship between MAP and PCOS using the PRISMA methodology. The review identified 214 records from PubMed, Cochrane, and Scopus databases, and 4 studies that met the inclusion criteria for qualitative assessment. Preliminary data suggest that MAP may contribute to the pathogenesis of PCOS via a number of mechanisms. This review highlights the need for greater awareness and further research on the effects of MAP in women with PCOS.

Keywords

polycystic ovary syndrome; microparticulate air pollution; inflammation; insulin resistance; metabolic; microbiome; environment; lifestyle

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

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