Yılmaz, S.; Küçükler, S.; Şimşek, H.; Aygörmez, S.; Kandemir, F.M. Naringin Protects Against Colistin-Induced Sciatic Nerve Damage by Reducing Oxidative Stress, Apoptosis and Inflammation Damage. Preprints2023, 2023090979. https://doi.org/10.20944/preprints202309.0979.v1
APA Style
Yılmaz, S., Küçükler, S., Şimşek, H., Aygörmez, S., & Kandemir, F.M. (2023). Naringin Protects Against Colistin-Induced Sciatic Nerve Damage by Reducing Oxidative Stress, Apoptosis and Inflammation Damage. Preprints. https://doi.org/10.20944/preprints202309.0979.v1
Chicago/Turabian Style
Yılmaz, S., Serpil Aygörmez and Fatih Mehmet Kandemir. 2023 "Naringin Protects Against Colistin-Induced Sciatic Nerve Damage by Reducing Oxidative Stress, Apoptosis and Inflammation Damage" Preprints. https://doi.org/10.20944/preprints202309.0979.v1
Abstract
Colistin is used in treatment against gram-negative bacteria. It causes toxic effects due to oxidative stress in a dose-dependent manner. Naringin is a flavonoid with strong antioxidant properties found naturally in many plants, especially citrus fruits. This study aimed to determine the protective effects of NRG in CLS-induced sciatic nerve injury. Thirty-five male Spraque rats were randomly divided into five groups: control, NRG, CLS, CLS+NRG50, and CLS+NRG100. CLS was administered orally at a 15mg/kg for seven days. NRG was administered orally at 50 or 100 mg/kg for seven days. CLS caused toxic damage in sciatic nerve tissue by increasing MDA and decreasing antioxidant capacity (SOD, CAT, GPx, and GSH); increasing NF-κB, TNF-α, nNOS release; increasing apoptotic factor (Caspase-3); decreasing HO-1 and nCAM; and inducing 8-OHdG, MAPK and GFAP. NRG, on the other hand, reversed all these changes in sciatic nerve tissue and reduced CLS-induced oxidative stress damage, inflammatory damage and apoptotic damage. These effects were more effective at the 100mg/kg dose of NRG than at the 50mg/kg dose. In sciatic nerve tissue, CLS-induced sciatic nerve toxicity with increased oxidative stress, inflammation, and apoptotic damage. NRG showed a protective effect against CLS-induced sciatic nerve toxicity.
Medicine and Pharmacology, Medicine and Pharmacology
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