Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Phenotypic Characterization of the Oldest Italian Men from December 28, 2020 to September 23, 2021, Antonino Turturici, Suggests a Role for Immune System in the Attainment of Extreme Longevity

Giulia Accardi
ORCID logo ,
Anna Aiello
ORCID logo ,
Stefano Aprile
,
Anna Calabrò
,
Rosalia Caldarella
,
Marcello Ciaccio
ORCID logo ,
Calogero Caruso
* ORCID logo ,
Francesco Dieli
ORCID logo ,
Mattia Emanuela Ligotti
,
Serena Meraviglia
ORCID logo ,
Giuseppina Candore
ORCID logo
Version 1 : Received: 12 September 2023 / Approved: 13 September 2023 / Online: 13 September 2023 (07:22:24 CEST)

A peer-reviewed article of this Preprint also exists.

Accardi, G.; Aiello, A.; Aprile, S.; Calabrò, A.; Caldarella, R.; Caruso, C.; Ciaccio, M.; Dieli, F.; Ligotti, M.E.; Meraviglia, S.; Candore, G. The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity. J. Clin. Med. 2023, 12, 7591. Accardi, G.; Aiello, A.; Aprile, S.; Calabrò, A.; Caldarella, R.; Caruso, C.; Ciaccio, M.; Dieli, F.; Ligotti, M.E.; Meraviglia, S.; Candore, G. The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity. J. Clin. Med. 2023, 12, 7591.

Abstract

In this paper, we present demographic, clinical, anamnestic, cognitive, and functional data, as well as haematological, haematochemical, immunological and genetic parameters of an exceptional individual: Antonino Turturici, a semi-supercentenarian who held the title of the oldest living Italian centenarian from December 28, 2020, to September 23, 2021. The purpose of this study is to offer fresh insights into extreme phenotypes, with a particular focus on immune-inflammatory parameters. To the best of our knowledge, this study represents the first phenotypic investigation of a semi-supercentenarian, illustrating both indicators of age-related immune phenotype (ARIP) recognized as significant gauges of biological ageing and INFLA-score, a metric designed to assess the cumulative impact of inflammatory markers. The aim of this study was, indeed, to advance our understanding of the role of immune-inflammatory responses in achieving extreme longevity. The results bolster the idea that the immune system can play a role in promoting extreme longevity. However, this does not exclude the involvement of other body systems or organs in achieving extreme longevity.

Keywords

Ageing; ARIP; Biological Ageing; Inflamm-ageing; INFLA-score; Lymphocyte subsets; Longevity; Semi-supercentenarian

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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