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Rising Cancer Impact and Pollution as Hazards

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Submitted:

04 September 2023

Posted:

05 September 2023

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Abstract
Comprehensive studies into the various causes of this ubiquitous disease have been prompted by the worldwide increase in cancer incidence. There are many potential causes of cancer, but environmental factors are of particular concern now. This abstract explores the complex link between environmental factors and the growing cancer epidemic, shedding light on the role that our immediate environment plays in the emergence of cancers. The environment can contain carcinogenic agents that gradually influence the course of cancer, including air pollutants, water contaminants, workplace exposures, and industrial activities. The ways through which environmental carcinogens may cause DNA damage and unchecked cell proliferation are discussed in this abstract. Environmental justice and the moral necessity to reduce inequities in exposure and health effects are highlighted to underline the disproportionate impact on vulnerable groups. The study presented here highlights the need for preemptive action to reduce environmental risks. Society can reduce the hidden threat posed by environmental carcinogens through strict legislation, sustainable practices, and community-driven initiatives. In order to lessen the cancer burden and secure a healthier future for all, the authors of this abstract argue that there must be a concerted effort to create surroundings that promote health and well-being.
Keywords: 
DNA; pollution; cancer; health
Subject: 
Public Health and Healthcare  -   Public Health and Health Services
Environmental and Health Issues and Solutions for Anticoccidials and other Emerging Pollutants of Special Concern

Introduction:

Even with all the improvements in medicine and technology, cancer is becoming increasingly common and devastating for everyone affected. The complex interplay between our environment and the diseases that plague us is often overlooked, despite the fact that it plays a significant role in cancer development alongside genetic predispositions and lifestyle decisions. Slowly but surely, people began to make the connection between their surroundings and cancer, revealing a web of risks that permeated every aspect of modern life. Cancer's connection to environmental carcinogens and pollutants is complex and needs to be investigated thoroughly. We are exposed to cancer-causing agents in our everyday environments, from the air we breathe and the water we drink to the things we use and the locations we live. As we make our way through this maze, we are forced to face the uncomfortable truth that our relentless pursuit of technological innovation and advancement has ocionally put our health at risk. The environmental elements that play a not-so-obvious but crucial part in the current cancer epidemic are the focus of this investigation. Understanding the precise environmental carcinogens and the processes by which they might activate cellular alterations that lead to malignant growth are just two of the many parts of this intricate interaction that are illuminated. This investigation goes beyond questions of personal safety to address issues of environmental justice, which arise because vulnerable populations are disproportionately affected by pollution and other environmental hazards 1-3.
We are aware of the significance of exposing the unseen dangers that lurk close by as we set out on this quest. By learning the specific ways in which our surroundings affect our risk of developing cancer, we can make better decisions, push for policy changes, and put the health of future generations first. In order to create a world where the environment fosters rather than undermines our well-being, this is a call to action to address the silent threat as a community.

Everyday Toxic Exposures: Investigating a Prominent Environmental Cause of Cancer

The environment we live in is filled with a wide variety of compounds that may have an effect on our health in today's more industrialized and urbanized society. Some of these, in particular, are more subtle than others and may be adding to the overall increase in cancer rates. This section digs into the unseen dangers that exist all around us: chemicals, contaminants, and compounds that, when mixed together, can create a poisonous symphony. Modern living inherently involves toxic exposures. It is possible to be exposed to harmful compounds in the environment through the air we breathe, the food we eat, the goods we use, and the locations we frequent. There is mounting evidence linking these exposures together as a whole to the ever-increasing cancer toll 4-6.
1. Cancer-Causing Substances in the Air:
Fine particulate matter (PM2.5), volatile organic compounds (VOCs), and nitrogen dioxide (NO2) are only some of the air pollutants that tend to accumulate in greater quantities in urban and industrial regions. Some of these contaminants are carcinogenic, and they have been associated to respiratory cancers like lung cancer. Diesel exhaust is a major source of cancer-causing polycyclic aromatic hydrocarbons (PAHs) in metropolitan areas.
2. Consumer goods and other items for the home:
Cleaning supplies, cosmetics, and plastics may all have endocrine-disrupting chemicals (EDCs) like phthalates and bisphenol-A (BPA) lurking in their formulas.
Many malignancies, particularly breast and prostate, have been linked to EDCs because of their ability to disrupt hormone systems.
3. Contaminants in Food and Pesticides:
Conventionally grown produce may have harmful pesticide residues, and seafood may include pollutants. International health agencies have labeled a few pesticides as "probable" or "possible" carcinogenic.
4. Dangers Present in Industry and the Workplace:
Asbestos, heavy metals, and chemical solvents are just some of the carcinogenic substances to which workers in industries like manufacturing, mining, and construction may be exposed on the job.
For example, asbestos has long been known to cause cancer in humans, including mesothelioma and lung cancer.
5. Water Pollution:
Contaminants such as arsenic, lead, and chlorination byproducts can be present in drinking water sources. The naturally occurring element arsenic has been associated to an increased risk of developing malignancies of the skin, lungs, and bladder.
6. Exposed to Radiation:
Radiation exposure, including that from medical imaging and some workplaces, can cause DNA damage and increase cancer risk.
7. Pollutant noise and emotional strain:
Noise pollution has been linked to stress and sleep disruptions, both of which have negative effects on the immune system and may lead to the onset of cancer.
8. Awareness as a Tool for Threat Reduction:
Individuals and communities can take educated steps toward risk reduction if they are aware of the wide variety of toxic exposures they face on a daily basis.
Choosing organic foods and cleaning supplies and reducing your exposure to hazardous substances are both individual choices that can help reduce your toxic load.
9. Advocacy: Bringing attention to the dangers of particular compounds can lead to shifts in manufacturing methods, product restrictions, and government policies aimed at protecting the environment. Supportive regulatory frameworks for public health protection can be informed by ongoing research into the health effects of various hazardous exposures. The hidden danger of toxic exposures calls for a comprehensive strategy to reduce cancer rates, including individual behavior modification, ecological consciousness, and group action. Knowledge is a powerful weapon in protecting our health and halting the growing tide of cancer incidence connected with toxic exposures as we navigate a world rife with potential hazards.

Exposing Environmental Cancer Causers: The Hunt for Carcinogens

Understanding the complex connection between environmental factors and the rising cancer burden places a premium on the hunt for unmasking carcinogenic substances. The goal of this investigation is to uncover the complex network of environmental factors that have been linked to the emergence of cancer. By illuminating these risks, we may better understand how they affect our health and what can be done to counteract them 7-14.
1. Asbestos, the Hidden Danger:
Asbestos is a notorious carcinogen linked to lung cancer and mesothelioma, although it is still widely utilized in construction and industry. When breathed in, its minute fibers lodge deep within the lungs, where they trigger inflammation and DNA damage over time.
2. The Industrial Villain, Benzene:
Benzene is a carcinogen linked to leukemia and other blood cancers; it is an industrial compound used in fuels, plastics, and chemicals. Workers' exposure to hazardous substances in businesses like petroleum refining raises serious safety and health concerns.
3. The Dangers of Formaldehyde:
Formaldehyde is a chemical that is found in many building supplies, adhesives, and fabrics, and it is suspected of causing cancer in humans. Nasopharyngeal carcinoma and leukemia have been linked to long-term exposure to formaldehyde.
4. The Persistent Pollutant Polychlorinated Biphenyls (PCBs):
PCBs, which were once widely employed in electrical and industrial applications, continue to accumulate in the environment and food chain. Several types of cancer, including liver and breast cancer, have been linked to them.
5. Exposure to Aromatic Amines in the Workplace:
Rubber, dyes, and plastics all contain aromatic amines, and these chemicals have been associated to an increased risk of bladder cancer. Concerns have been raised about the exposure of workers in the chemical, textile, and rubber industries.
6. Arsenic: A Silent Killer When Eaten:
Arsenic is linked to skin, lung, bladder, and liver cancers, and it is found in contaminated water and some foods. Water contamination in some areas has led to chronic exposure to elevated arsenic levels.
7. The Invisible Threat of Radon:
Second only to smoking as a cause of lung cancer is radon, a radioactive gas that rises from the earth. It can build up in closed-off, poorly ventilated spaces like offices and residences.
8. Cancer-Causing Properties of Cigarette Smoke:
Numerous carcinogenic substances are present in cigarette smoke and contribute directly to the development of malignancies of the lung, throat, and other organs.
9. The Downside of Sunlight Is Ultraviolet (UV) Radiation:
Sunlight and artificial tanning sources, such as sunlamps and tanning booths, are major contributors to the development of skin cancer, including melanomas.
10. Carcinogens in Food: The Unknown Connection:
Consumption of processed meats containing nitrates, for example, has been linked to an increased risk of developing cancer.
11. Chemicals that disrupt hormones are called endocrine disruptors (EDCs).
Plastics, insecticides, and cosmetics all contain endocrine disrupting chemicals (EDCs), which can disrupt hormone systems and increase the risk of developing hormone-related cancers. In the ongoing fight against rising cancer rates, the identification of carcinogenic substances is a crucial step. Individuals, communities, and policymakers can take action to decrease their exposure to harmful drugs once they are aware of those substances. This comprehension highlights the need for more stringent laws, educated consumer decisions, and public health actions to protect against these covert carcinogens.

Exploring the Connection between Airborne Hazards and Rising Cancer Rates

The air we breathe is not only necessary for survival, but it also transports invisible dangers that can have serious effects on our wellbeing. Significant factors in the rising cancer rates have been identified as airborne risks, especially in the forms of air pollution and indoor air quality. This in-depth investigation investigates the complex connection between airborne pollution, carcinogens, and the alarming increase in cancer incidence 14-19.
1. Cancer-Causing Substances in Outdoor Air Pollution:
Particulate matter (PM), nitrogen dioxide (NO2), sulfur dioxide (SO2), and volatile organic compounds (VOCs) are only some of the outdoor air pollutants that have increased as a result of urbanization and industrialization. Vehicle exhaust and industrial activities release carcinogenic substances such the volatile organic compound (VOC) benzene. These toxins are taken into the lungs and systemic circulation through inhalation.
2. Airborne ps (PM) and the Risk of Lung Cancer:
A higher exposure to both PM2.5 and PM10 has been associated with an increased risk of lung cancer.
- Particulate matter (PM) can transport carcinogens or stimulate oxidative stress and inflammation, all of which can cause DNA damage and cellular alterations that fuel the growth of cancer.
3. Indoor Air Pollution and Other Health Risks in the Home:
Since most of our waking hours are spent inside, maintaining healthy indoor air quality is essential. Secondhand smoking, radon gas, asbestos fibers, and volatile organic compounds (VOCs) from common household goods are all examples of common indoor contaminants.
4. Lung cancer and radon exposure:
The radioactive gas radon, found in soil, can enter buildings and build up to unsafe levels. Radon is the second leading cause of lung cancer, right after cigarette smoking.
5. Second hand smoke and exposure:
There are more than 70 carcinogens identified in tobacco smoke, making it a major cause of lung cancer and other forms of the disease.
Nonsmokers who are exposed to secondhand smoke, especially in enclosed spaces, have an increased chance of developing cancer.
6. Workplace Dangers:
Asbestos fibers, formaldehyde, and diesel exhaust are just a few of the airborne carcinogens that workers in certain industries are subjected to. Construction workers, miners, and factory workers are at a higher risk for developing lung and other types of cancer.
7. Carcinogenesis and Its Causes:
Airborne carcinogens can cause DNA damage in two ways: directly through interactions, or indirectly through the promotion of inflammation and oxidative stress. The accumulation of mutations and abnormalities in the DNA of cells can cause them to mutate and eventually become cancerous.
8. Impact Reduction through Community Health Programs:
The need of taking preventative actions to limit exposure to airborne dangers in cancer development is highlighted by this realization. Environmental policies can reduce cancer risks by enforcing stricter limits on human exposure to pollutants in the air. Indoor air quality can be improved and cancer risk reduced by proper ventilation, smoking prohibitions, and radon monitoring. Protecting employees in high-risk sectors requires strict safety procedures and the use of personal protective equipment.
9. Easy Breathing, Healthier Living:
The rising cancer rate is mostly attributable to airborne risks, which pose a serious threat to public health. The interconnectivity of our environment and our health is shown by the link between outdoor and interior air pollution and cancer. As we work to overcome these obstacles, our joint efforts to reduce exposure to airborne carcinogens will determine whether or not clean air remains a luxury or a human right in the future. In order to make educated decisions, advocate for cleaner surroundings, and breathe easier in our pursuit of better lives, it is crucial to comprehend the nuanced pathways connecting airborne dangers and cancer.

Cancer and Water Pollutants:

Water is essential to life, yet it may also be used to cause harm. There is growing worry about the effects of chemicals, poisons, and pollutants found in water on human health, especially their possible role in the etiology of cancer. Understanding the methods, sources, and implications of this often-overlooked hazard is the focus of this investigation into the connection between aquatic toxins and the increased incidence of cancer 20-25.
1. Inorganic Arsenic in Potable Water:
Groundwater in various parts of the world contains naturally occurring arsenic.
Cancers of the skin, bladder, and lungs have all been related to long-term exposure to arsenic in drinking water.
2. Cancer and Heavy Metals:
Heavy metals such as lead, cadmium, and mercury can contaminate water supplies through urban and industrial runoff. Long-term contact with certain metals raises the risk of developing several malignancies, most notably kidney and lung cancers.
3. Pollution from Industrial Chemicals in Water:
Chemicals such as polychlorinated biphenyls (PCBs) and chlorinated solvents are released into water sources through industrial activities. There is evidence linking PCB exposure to several different types of cancer, including those of the liver and skin.
4. Products of Chlorination:
Disinfection byproducts (DBPs) like trihalomethanes can be produced during the chlorine disinfection process. The chance of developing bladder and colorectal malignancies increases with prolonged contact with DBPs.
5. Chemicals that Mess with Your Hormones
Bisphenol-A (BPA) and other endocrine-disrupting chemicals (EDCs) can seep into water supplies via plastics and other consumer goods. Breast and prostate cancers, both of which are influenced by hormones, have been associated to a subset of EDCs.
6. Pollution from Farming and Pesticides:
Agricultural runoff can contaminate water supplies with harmful chemicals like pesticides and herbicides. Some pesticides are suspected or known to cause cancer and should be avoided.
7. Pollution of Drinking Water Supplies:
Populations may be exposed to multiple carcinogens if contaminated water makes its way into their drinking water supply.
8. Implications for Health and How They Work:
The seriousness of the problem is shown by research into the mechanisms through which aquatic pollutants cause cancer. Mutations and cancer caused by DNA damage directly damage DNA.
9. Hormone Disruption: Endocrine-disrupting substances may have a role in hormone-related malignancies through interfering with hormone signaling. Both inflammation and oxidative stress have been linked to the development of cancer, and exposure to some pollutants can amplify both processes.
10. Reducing Danger and Protecting Drinking Water:
Together, we can protect our aquatic ecosystems and our drinking water from the dangers of waterborne pollutants. Removing pollutants and disinfecting water with cutting-edge technologies without producing dangerous byproducts is what we mean by "water treatment." Source protection refers to the practice of implementing watershed management measures to stop agricultural runoff and industrial discharges from polluting water supplies. Monitoring and enforcing new rules to reduce pollutant levels in water supplies is part of regulatory oversight. Contaminants in water pose a serious threat to public health, weaving themselves into the intricate web of factors that can lead to cancer. The crucial need of protecting water quality for present and future generations is highlighted by the complex relationship between water contaminants and cancer incidence. To ensure that the gift of clean water continues to be a cornerstone of collective well-being, we must acknowledge the potential threat posed by waterborne contaminants, advocate for stringent regulations, and support technologies that ensure clean water.
Increased Cancer Burden Due to Occupational and Industrial Carcinogens:
Despite its reputation as a hub of creativity and productivity, the office can really pose serious threats to employees' well-being. The term "occupational and industrial carcinogens" refers to cancer-causing compounds found in many workplaces and industries. Through illuminating the mechanisms, industries, and preventative methods, this in-depth investigation dives into the complicated relationship between workplace exposures, industrial practices, and the increased burden of cancer incidence 26-29.
1. Contamination with Asbestos and the Development of Mesothelioma:
Asbestos is a naturally occurring mineral that was utilized extensively because to its high resistance to fire. Mesothelioma is a rare but deadly cancer that attacks the lining of the lungs and other organs; it is caused by inhaling asbestos fibers.
2. The Metalworking and Heavy Metals Industries:
Chromium, cadmium, and nickel are just a few of the heavy metals that can be found in the environments of industries like metalworking, welding, and smelting. These metals have been linked to several forms of cancer in humans, including those of the lung, bladder, and others.
3. Production of Chemicals and Cancer-Causing Substances:
Carcinogens such as benzene, formaldehyde, and vinyl chloride may be present in the workplaces of chemical manufacturers. Benzene is a carcinogen that has been related to leukemia and is utilized in the manufacturing of many different chemicals.
4. Buildings and Building Supplies:
Asbestos, silica, and wood dust are just some of the carcinogens that construction and building materials workers may be exposed to on the job. Cutting and drilling create silica dust, which has been linked to lung cancer and silicosis.
5. Farming and Environmental Risks:
Pesticides, herbicides, and other chemicals used in farming represent a health risk to those who work in the industry. Some pesticides have been linked to an increased risk of cancer in humans, earning them the label of "possible" or "probable."
6. Healthcare and the Dangers Associated with Receiving It:
Radiology and anesthesia professionals, for example, may be exposed to ionizing radiation and anesthetic gases in the course of their employment. Exposure to ionizing radiation from medical imaging, especially on a regular basis, can raise the risk of cancer.
7. Safety Precautions and Employee Coverage:
The need for stringent preventative measures is prompted by the recognition of the dangers posed by occupational and industrial carcinogens. Adherence to safety requirements in high-risk businesses and strict enforcement of regulations to reduce exposure to carcinogens. Workers should be provided with respirators and other protective equipment, and engineering controls should be put in place to reduce the likelihood of exposure. Risks, safe procedures, and the value of routine health checks can all be better understood and managed if employees are educated and aware of them.
8. The Importance of Protecting Employee Health:
The prevalence of occupational and industrial carcinogens highlights the value of a secure and healthy workplace. The importance of prioritizing worker safety, advocating for stringent rules, and investing in preventative measures is shown when we explore the complex relationship between occupational exposures and cancer incidence. By acknowledging the hazards posed by occupational and industrial carcinogens, businesses and governments alike take a step toward a future where the health and safety of every worker is of paramount importance, where increased output does not come at the expense of employees' physical or mental well-being.

Analyzing Contemporary Dangers and Their Possible Effect on Cancer Rates:

The environment faces increasing threats in today's dynamic world, some of which may have severe effects on human health. Electronic trash, innovative chemicals, and growing urbanization are only a few examples of the new environmental challenges that pose far-reaching risks. This investigation dives into the mechanisms, consequences, and proactive solutions for mitigating risks associated with the complex interplay between these contemporary concerns and their possible long-term impact on cancer rates 30-33.
1. Cancer and E-Waste (Electronic Waste):
Heavy metals, flame retardants, and toxic compounds are just some of the dangers hiding in electronic waste. Careless treatment and disposal of electronic trash can cause the release of carcinogenic compounds into the environment, which may increase the risk of developing cancer.
2. Disruption of Hormonal Systems by New Chemicals:
Concerns have been raised about the effects of recently developed and widely used chemicals, such as flame retardants and plastic additives, on human health. There is concern that exposure to certain substances may increase the chance of developing malignancies connected to the endocrine system.
3. Exposure to Urban Environments:
Air pollution, emissions from vehicles, and the loss of open space are all on the rise in areas where population density is high. Polluted air, water, and soil may increase the risk of cancer for city dwellers.
4. ALAN and the Disruption of the Circadian Rhythm:
Overexposure to artificial light at night decreases melatonin production and alters natural circadian rhythms. The risk of developing cancer, and notably breast cancer, has been linked to a disruption of circadian rhythms.
5. Pollutants in the environment, especially microplastics and POPs:
Microplastics, which originate from plastic debris, have been shown to take up and move persistent organic pollutants (POPs) throughout water systems. Polychlorinated biphenyls (PCBs) are just one example of a persistent organic pollutant that has been linked to cancer and can build up in the food chain.
6. Nanops in the Air and Lung Function:
Nanops released during industrial processes or combustion can be inhaled into the lungs, where they may release cancer-causing toxins. Lung cancer and other respiratory illnesses may be exacerbated by prolonged exposure to these ps.
7. Problem-Solving Through Forward Thinking:
Regulatory Frameworks to Control Use, Disposal, and Production of Dangerous Substances; and Promoting Innovation to Foster Safer Substitutes. Planning for cities that minimize environmental impacts by maximizing the use of green space, lowering pollution levels, and encouraging the use of environmentally friendly modes of transportation is known as sustainable urban planning. Management of electronic waste involves using safe methods of disposing of old electronics so as to limit the discharge of cancer-causing chemicals into the atmosphere. The need for constant attention, adaptability, and innovation to protect human health in the face of emerging environmental problems is clear. We recognize the connection of environment and health as we investigate the complex link between contemporary risks and cancer rates. We set out on a journey toward a future where human health and environmental vitality coexist harmoniously by adopting sustainable practices, advocating for stringent regulations, and raising awareness about these challenges. This is a future where the threats posed by emerging environmental challenges are met with informed action, resilience, and a commitment to a healthier world.

Environmental Justice and Community Health:

While we are all susceptible to the effects of environmental risks, not everyone feels them in the same ways. A disproportionate share of the cancer risks associated with exposure to carcinogenic chemicals falls on already vulnerable populations. An important part of public health, environmental justice stresses the importance of eliminating these inequalities and guaranteeing everyone the chance to grow up in a safe and secure setting. This investigation illuminates the methods, ramifications, and avenues toward equitable health by delving into the complex connection between community health, environmental justice, and cancer prevention 33.
1. Community Vulnerability and Environmental Disparities:
Due to variables like as proximity to industrial facilities and a lack of regulatory compliance, low-income areas and communities of color often suffer greater levels of environmental dangers. In addition to inadequate access to healthcare services, these communities frequently lack the means to reduce their risk of exposure.
2. Neighborhoods and Industrial Pollution:
Greater exposure to pollutants and carcinogens occurs when industrial operations are located in or near disadvantaged neighborhoods. Air pollution and hazardous pollutants from these factories have been linked to increased rates of cancer and other diseases.
3. Racism and the Pollution of Water Supplies:
Water contamination is a problem in some areas because of outdated infrastructure and lax oversight. The lead-tainted water supply in Flint, Michigan, and other similar incidents, highlight the widespread lack of access to safe drinking water.
4. Dangers in the Workplace and the Most at Risk Employees:
Workers in low-wage occupations like agriculture and industry, where carcinogen exposure is common, have a higher risk of developing the disease. These inequalities are exacerbated by the lack of access to safety gear and occupational health services.
5. Consequences of Long-Term Exposure:
The health risks faced by vulnerable people are typically exacerbated by their exposure to several environmental dangers. An increased incidence of cancer and other diseases may occur from repeated exposures.
6. Advocate and policy intervention strategies:
To safeguard vulnerable populations, policies that restrict emissions, pollution, and the generation of hazardous waste must be enforced and strengthened.

Conclusion:

Making preventative care, screenings, and treatment available to those who might not otherwise be able to afford it. Environmental justice and the war on cancer are inextricably intertwined. The disproportionate effect of environmental carcinogens on marginalized groups should serve as a reminder of the need to eliminate structural inequalities. We set out on a path toward a future where community health and environmental justice intersect, a future where every person has the chance to thrive in an environment free from carcinogenic exposures, by promoting policies that prioritize the health and well-being of all individuals, regardless of their socioeconomic status or background. Environmental variables have emerged as an important, albeit frequently underappreciated, cog in the complex web of cancer causation. Our exploration of carcinogenic chemicals, occupational exposures, and new threats has led us to a sobering conclusion: the air we breathe, the water we drink, and the soil we cultivate can all offer serious risks to our health. Because of the complex relationship between modernity and health, reducing the effects of environmental carcinogens is an urgent priority in light of the rising cancer burden. At the end of our investigation, it is clear that the environmental elements constitute a quiet threat that requires collective action and societal commitment. There must be a comprehensive strategy to address environmental problems, from lobbying for more stringent rules and sustainable practices to promoting environmental justice for vulnerable populations. In order to make educated decisions, influence policy changes, and create healthier living environments, we need a better understanding of the mechanisms by which environmental carcinogens originate and promote cancer development. An interdisciplinary strategy that unites science, policy, and public education is needed to combat the increasing cancer incidence attributable to environmental factors. It urges us to evaluate our present ways of doing things, to wonder if our development is truly sustainable, and to put the wellbeing of Earth and its inhabitants first. Environmental dangers are reduced, inequalities are narrowed, and cancer's stranglehold on society is lessened thanks to our efforts in the areas of education, lobbying, and transformative projects. In the end, the strong association between environmental issues and the growing cancer burden highlights the interconnected nature of human health and environmental sustainability. Our path forward toward a healthier, more harmonious coexistence will be determined by our capacity to comprehend, adapt to, and steer change in this environment. This fight is about more than just solving problems in the here and now; it's also about protecting future generations from harm, and making the silent menace into an armed force for good in the fight to end cancer forever.

References

  1. WHO. (2023). Cancer, Key facts. [https://www.who.int/news-room/fact-sheets/detail/cancer](https://www.who.int/news-room/fact-sheets/detail/cancer). Accessed June 20, 2020.
  2. Iran Ministry of Health and Medical Education. Non-communicable Disease Management Center. Cancer Department. (2019). National Report of the National Cancer Registration Program for 2015.
  3. Zhu, F., et al. (2019). The short-term effects of air pollution on respiratory diseases and lung cancer mortality in Hefei: A time-series analysis. Respiratory Medicine, 146, 57–65. [CrossRef]
  4. Coker, E., Liverani, S., Su, J. G., & Molitor, J. (2018). Multi-pollutant modeling through examination of susceptible subpopulations using profile regression. Current Environmental Health Reports, 5(1), 59–69. [CrossRef]
  5. Han, Y., et al. (2016). Association between size-segregated particles in ambient air and acute respiratory inflammation. Science of the Total Environment, 565, 412–419. [CrossRef]
  6. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. (2016). IARC Monographs Volume 109: Outdoor Air Pollution. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, 7.
  7. Hvidtfeldt, U., et al. (2019). Low-level ambient air pollution exposure and risk of lung cancer: A pooled analysis of 7 European cohorts. Environmental Epidemiology, 3, 171. [CrossRef]
  8. Dominici, F., Peng, R. D., Barr, C. D., & Bell, M. L. (2010). Protecting human health from air pollution: Shifting from a single-pollutant to a multi-pollutant approach. Epidemiology, 21(2), 187.
  9. Taylor, K. W., et al. (2016). Statistical approaches for assessing health effects of environmental chemical mixtures in epidemiology: Lessons from an innovative workshop. Environmental Health Perspectives, 124(12), A227–A229. [CrossRef]
  10. Stafoggia, M., Breitner, S., Hampel, R., & Basagaña, X. (2017). Statistical approaches to address multi-pollutant mixtures and multiple exposures: The state of the science. Current Environmental Health Reports, 4(4), 481–490. [CrossRef]
  11. Davalos, A. D., Luben, T. J., Herring, A. H., & Sacks, J. D. (2017). Current approaches used in epidemiologic studies to examine short-term multipollutant air pollution exposures. Annals of Epidemiology, 27(2), 145–153. [CrossRef]
  12. Caban-Martinez, A. J., Santiago, K. M., Baum, J., & Solle, N. N. S. (2020). Silicone-based wristband passive samplers in the detection of firefighter occupational carcinogenic exposures. Cancer Prevention Research, 13, 45. [CrossRef]
  13. Kolpacoff, V. L. (2019). Latent Class Modeling of Environmental Exposures for North Carolina at the Census Tract Level.
  14. Hagenaars, J. A., & McCutcheon, A. L. (2002). Applied Latent Class Analysis. Cambridge University Press. [CrossRef]
  15. Guo, H., Chang, Z., Wu, J., & Li, W. (2019). Air pollution and lung cancer incidence in China: Who are faced with a greater effect? Environment International, 132, 105077.
  16. Fuller, C. H., Feeser, K. R., Sarnat, J. A., & O’Neill, M. S. (2017). Air pollution, cardiovascular endpoints, and susceptibility by stress and material resources: A systematic review of the evidence. Environmental Health, 16(1), 58. [CrossRef]
  17. UNFPA Iran. (n.d.). Population study and census data from the Statistical Center of Iran. [https://iran.unfpa.org/Documents/Census2011/2011%20Census%20Selected%20Results%20-%20Eng.pdf](https://iran.unfpa.org/Documents/Census2011/2011%20Census%20Selected%20Results%20-%20Eng.pdf). Accessed June 20, 2023.
  18. Amini, H., et al. (2014). Land use regression models to estimate the annual and seasonal spatial variability of sulfur dioxide and particulate matter in Tehran, Iran. Scientific Reports, 488, 343–353. [CrossRef]
  19. Amini, H., et al. (2016). Annual and seasonal spatial models for nitrogen oxides in Tehran, Iran. Scientific Reports, 6(1), 1–11. [CrossRef]
  20. Amini, H., et al. (2017). Spatiotemporal description of BTEX volatile organic compounds in a Middle Eastern megacity: Tehran study of exposure prediction for environmental health research (Tehran SEPEHR). Environmental Pollution, 226, 219–229. [CrossRef]
  21. Amini, H., Schindler, C., Hosseini, V., Yunesian, M., & Künzli, N. (2017). Land use regression models for Alkylbenzenes in a middle eastern megacity: Tehran study of exposure prediction for environmental Health Research (Tehran SEPEHR). Environmental Science & Technology, 51 (15), 8481–8490. [CrossRef]
  22. Malla, M. A., Dubey, A., Kumar, A., Patil, A., Ahmad, S., Kothari, R., & Yadav, S. (2021). Optimization and elucidation of organophosphorus and pyrethroid degradation pathways by a novel bacterial consortium C3 using RSM and GC-MS-based metabolomics. Journal of the Taiwan Institute of Chemical Engineers, 144, 104744. [CrossRef]
  23. Munot, N., Kandekar, U., Rikame, C., Patil, A., Sengupta, P., Urooj, S., & Bilal, A. (2022). Improved Mucoadhesion, Permeation and In Vitro Anticancer Potential of Synthesized Thiolated Acacia and Karaya Gum Combination: A Systematic Study. Molecules, 27(20), 6829. [CrossRef]
  24. Munot, N., Kandekar, U., Giram, P. S., Khot, K., Patil, A., & Cavalu, S. (2022). A Comparative Study of Quercetin-Loaded Nanocochleates and Liposomes: Formulation, Characterization, Assessment of Degradation and In Vitro Anticancer Potential. Pharmaceutics, 14(8), 1601. [CrossRef]
  25. Manikyam, H. K., Tripathi, P., Patil, S. B., Lamichhane, J., Chaitanya, M., & et al. (2020). Extraction, purification, and quantification of hesperidin from the immature Citrus grandis/maxima fruit Nepal cultivar. Asian Journal of Natural Product Biochemistry, 20(1). [CrossRef]
  26. Patil, A., Munot, N., Patwekar, M., Patwekar, F., Ahmad, I., Alraey, Y., & Alghamdi, S., & et al. (2022). Encapsulation of lactic acid bacteria by lyophilisation with its effects on viability and adhesion properties. Evidence-based Complementary and Alternative Medicine, 2022. [CrossRef]
  27. Nalawade, A. S., Gurav, R. V., Patil, A. R., Patwekar, M., & Patwekar, F. (2022). A comprehensive review on morphological, genetic and phytochemical diversity, breeding and bioprospecting studies of genus Chlorophytum Ker Gawl. from India. Trends in Phytochemical Research, 6(1), 19-45.
  28. Patil, K. G., Balkundhi, S., Joshi, H., & Ghewade, G. (2011). MEHSANA BUFFALO MILK AS PREBIOTICS FOR GROWTH OF LACTOBACILLUS. International Journal of Pharmacy and Pharmaceutical Research, 1(1), 114-117.
  29. Das, N., Ray, N., Patil, A. R., Saini, S. S., Waghmode, B., Ghosh, C., & Patil, S. B., & et al. (2022). Inhibitory effect of selected Indian honey on colon cancer cell growth by inducing apoptosis and targeting the β-catenin/Wnt pathway. Food & Function, 13(15), 8283-8303. [CrossRef]
  30. Patil, M. J., & Mali, V. (2021). The Diverse Cytotoxicity Evaluation of Lactobacillus Discovered from Sheep Milk. Acta Scientific Pharmaceutical Sciences, 5(12), 69-70.
  31. Abhinandan, P. S. P., & John, D. (2020). Probiotic potential of Lactobacillus plantarum with the cell adhesion properties. Journal of Global Pharma Technology, 10(12), 1-6.
  32. Patil, A., Pawar, S., & Disouza, J. (2018). Granules of unistrain lactobacillus as nutraceutical antioxidant agent. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 9(4), 1594-1599.
  33. Patil, A., Mali, V., & Patil, R. (2019). Banana fibers camouflaging as a gut worm in a 6-month-old infant. Iberoamerican Journal of Medicine, 2(3), 245-247. [CrossRef]
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