Hispidulin Inhibits Vascular Inflammation Triggered by Porphyromonas gingivalis Lipopolysaccharide

Yeon Kim; Hoyong Lee; Hyun-Joo Park; Mi-Kyoung Kim; Yong-Il Kim; Hyung Joon Kim; Soo-Kyung Bae; Yung-Jin Kim; Moon-Kyoung Bae

doi:10.20944/preprints202309.0155.v1

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preprints.org > medicine and pharmacology > medicine and pharmacology > doi: 10.20944/preprints202309.0155.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Hispidulin Inhibits Vascular Inflammation Triggered by Porphyromonas gingivalis Lipopolysaccharide

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Version 1 : Received: 1 September 2023 / Approved: 4 September 2023 / Online: 5 September 2023 (05:01:52 CEST)

A peer-reviewed article of this Preprint also exists.

Kim, Y.; Lee, H.; Park, H.-J.; Kim, M.-K.; Kim, Y.-I.; Kim, H.J.; Bae, S.-K.; Kim, Y.-J.; Bae, M.-K. Hispidulin Inhibits the Vascular Inflammation Triggered by Porphyromonas gingivalis Lipopolysaccharide. Molecules 2023, 28, 6717. Kim, Y.; Lee, H.; Park, H.-J.; Kim, M.-K.; Kim, Y.-I.; Kim, H.J.; Bae, S.-K.; Kim, Y.-J.; Bae, M.-K. Hispidulin Inhibits the Vascular Inflammation Triggered by Porphyromonas gingivalis Lipopolysaccharide. Molecules 2023, 28, 6717.

Abstract

Hispidulin is a natural bioactive flavonoid that has been studied for its potential therapeutic properties, including its anti-inflammatory, antioxidant, and neuroprotective effects. The aim of this study was to explore whether hispidulin could inhibit endothelial inflammation triggered by Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS). The adhesion of monocytes to vascular endothelium was evaluated by in vitro and ex vivo monocyte adhesion assays. We analyze the migration of monocytes across the endothelial layer using transmigration assay. The result showed that treatment with hispidulin decreased P. gingivalis LPS-induced the adhesion of monocytes to endothelial cells and their migration by suppressing P. gingivalis LPS-triggered expression of intercellular adhesion molecule-1 (ICAM-1) through downregulating nuclear factor-қB (NF-қB). In addition, hispidulin inhibited P. gingivalis LPS-induced mitogen-activated protein kinases (MAPKs) and AKT in endothelial cells. Altogether, the results indicate that hispidulin suppresses vascular inflammation induced by P. gingivalis LPS. Mechanistically, it prevents the adhesion of monocytes to the vascular endothelium and migration and inhibits NF-қB, MAPKs, and AKT signaling in endothelial cells.

Keywords

hispidulin; Porphyromonas gingivalis; lipopolysaccharide; monocyte; vascular endothelial cells; vascular inflammation

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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