Article
Version 1
Preserved in Portico This version is not peer-reviewed
Analysis of Opioid-Related Adverse Events in Japan
Version 1
: Received: 31 August 2023 / Approved: 1 September 2023 / Online: 4 September 2023 (04:07:36 CEST)
A peer-reviewed article of this Preprint also exists.
Hirai, R.; Uesawa, Y. Analysis of Opioid-Related Adverse Events in Japan Using FAERS Database. Pharmaceuticals 2023, 16, 1541. Hirai, R.; Uesawa, Y. Analysis of Opioid-Related Adverse Events in Japan Using FAERS Database. Pharmaceuticals 2023, 16, 1541.
Abstract
Adverse events associated with opioid use in palliative care have been extensively studied. However, predicting the occurrence of adverse events based on the specific opioid used remains unclear. This study aimed to comprehensively analyze the adverse events caused by µ receptor stimulation of opioids approved in Japan and investigate the tendencies of adverse event occur-rence among different opioids.We utilized the FDA Adverse Event Reporting System (FAERS) database to extract reported adverse events of opioids approved in Japan. Cluster analysis was performed on reporting odds ratios (RORs) of adverse event names among opioids to visualize relationships between opioids and adverse events, facilitating a comparative study of their clas-sifications.We calculated the RORs of adverse events for the target opioids. Based on these RORs, we performed a cluster analysis, which resulted in the classification of 11 target opioids into five distinct groups. we were able to comprehensively compare and examine the relationships between opioids and adverse events. This analysis helps in understanding and managing the risks and benefits of each drug in palliative care settings. By analyzing relationships between opioids and adverse events, clinicians can make informed decisions about opioid selection, dosage, and monitoring to maximize patient safety and comfort.
Keywords
opioids; adverse effect database; FAERS, reporting odds ratio; cluster analysis
Subject
Medicine and Pharmacology, Anesthesiology and Pain Medicine
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
