Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Role of Adjuvant Radiotherapy in Patients with Cervical Cancer Undergoing Radical Hysterectomy

Maria Alonso-Espias
,
Mikel Gorostidi
* ORCID logo ,
Myriam Gracia
,
Virginia Garcia-Pineda
,
María Dolores Diestro
,
Jaime Siegrist
ORCID logo ,
Alicia Hernández
,
Ignacio Zapardiel
Version 1 : Received: 31 August 2023 / Approved: 1 September 2023 / Online: 4 September 2023 (04:06:24 CEST)

A peer-reviewed article of this Preprint also exists.

Alonso-Espías, M.; Gorostidi, M.; Gracia, M.; García-Pineda, V.; Diestro, M.D.; Siegrist, J.; Hernández, A.; Zapardiel, I. Role of Adjuvant Radiotherapy in Patients with Cervical Cancer Undergoing Radical Hysterectomy. J. Pers. Med. 2023, 13, 1486. Alonso-Espías, M.; Gorostidi, M.; Gracia, M.; García-Pineda, V.; Diestro, M.D.; Siegrist, J.; Hernández, A.; Zapardiel, I. Role of Adjuvant Radiotherapy in Patients with Cervical Cancer Undergoing Radical Hysterectomy. J. Pers. Med. 2023, 13, 1486.

Abstract

The benefit of adjuvant radiotherapy (RT) after radical hysterectomy in patients with cervical cancer remains controversial. The aim of this study was to determine the impact on survival of adjuvant RT according to the Sedlis criteria. Patients with early-stage cervical cancer who underwent radical hysterectomy between 2005 and 2022 at a single tertiary institution were included. A multivariate analysis was performed to determinate if RT was an independent prognostic factor for recurrence or death. We also analyzed whether there was a statistically significant difference in overall survival (OS) between patients who met only one or two Sedlis criteria, depending on whether they received adjuvant RT or not. In this retrospective study 121 patients were included of whom 48(39.7%) received adjuvant RT due to the presence of unfavorable pathological findings. In multivariate analysis, RT was not found to be a statistically significant prognostic factor for OS (p=0.584) or disease-free survival (DFS) (p=0.559). When comparing patients who met one or two Sedlis criteria, there were no statistically significant differences in OS between RT and no adjuvant treatment in either group. Since the selection of patients with cervical cancer eligible for surgery is becoming more accurate, adjuvant RT might not be necessary for patients with intermediate-risk factors.

Keywords

cervical cancer; intermediate-risk factors; adjuvant radiotherapy

Subject

Public Health and Healthcare, Public Health and Health Services

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.