Personalized Arrhythmic Risk Stratification for Sudden Cardiac Death in Ischemic, Non-ischemic, and Hypertrophic Cardiomyopathy Patients: The Two-Step, Non-invasive Risk Factors Guiding to Electrophysiology Study Approach

Petros Arsenos; Athanasios Kordalis; Polychronis Dilaveris; Ioannis Doundoulakis; Christos-Konstantinos Antoniou; Aggeliki Laina; Nikias Milaras; Anastasia Xintarakou; Dimitris Tsiachris; Skevos Sideris; Konstantinos Toutouzas; Konstantinos Tsioufis; Konstantinos A Gatzoulis

doi:10.20944/preprints202308.2203.v1

How to cite: Arsenos, P.; Kordalis, A.; Dilaveris, P.; Doundoulakis, I.; Antoniou, C.; Laina, A.; Milaras, N.; Xintarakou, A.; Tsiachris, D.; Sideris, S.; Toutouzas, K.; Tsioufis, K.; Gatzoulis, K.A. Personalized Arrhythmic Risk Stratification for Sudden Cardiac Death in Ischemic, Non-ischemic, and Hypertrophic Cardiomyopathy Patients: The Two-Step, Non-invasive Risk Factors Guiding to Electrophysiology Study Approach. Preprints 2023, 2023082203. https://doi.org/10.20944/preprints202308.2203.v1 Arsenos, P.; Kordalis, A.; Dilaveris, P.; Doundoulakis, I.; Antoniou, C.; Laina, A.; Milaras, N.; Xintarakou, A.; Tsiachris, D.; Sideris, S.; Toutouzas, K.; Tsioufis, K.; Gatzoulis, K.A. Personalized Arrhythmic Risk Stratification for Sudden Cardiac Death in Ischemic, Non-ischemic, and Hypertrophic Cardiomyopathy Patients: The Two-Step, Non-invasive Risk Factors Guiding to Electrophysiology Study Approach. Preprints 2023, 2023082203. https://doi.org/10.20944/preprints202308.2203.v1

Abstract

Arrhythmic sudden cardiac death (SCD) has an annual prevalence of 1 per 1000 while 75% of the victims suffer from ischemic and 10% from non-ischemic or hypertrophic cardiomyopathy. Altogether, these three entities account for more than 80% of the total SCD victims. Guidelines for implantable cardiac defibrillators are still dominated by LVEF<30% from the MADIT II study. In terms of arrhythmic risk stratification, the PRESERVE-EF study restored in clinical practice the two-step arrhythmic risk stratification approach based on Electrocardiographic non-invasive risk factors (NIRFs) guiding to electrophysiological study. In our times with the multiple cardiac imaging methods and artificial intelligence applications availability, this two-step approach based on integrated arrhythmia mechanisms detection, emerges as an efficient SCD risk stratification paradigm for these three entities but also for the patients with congenital heart disease.

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Personalized Arrhythmic Risk Stratification for Sudden Cardiac Death in Ischemic, Non-ischemic, and Hypertrophic Cardiomyopathy Patients: The Two-Step, Non-invasive Risk Factors Guiding to Electrophysiology Study Approach

Abstract

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